Metabolic Adaptations in Cancer Stem Cells

Frontiers in Oncology
Umesh Prasad YadavKapil Mehta

Abstract

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer cells with remarkable ability to initiate, propagate, and spread the malignant disease. In addition, they exhibit increased resistance to anticancer therapies, thereby contributing to disease relapse. CSCs are reported to be present in many tumor types such as melanoma, sarcoma, mammary tumors, colon cancer and other solid tumors. These cells from different tumors show unique energetic and metabolic pathways. For example, CSCs from one type of tumor may predominantly use aerobic glycolysis, while from another tumor type may utilize oxidative phosphorylation. Most commonly these cells use fatty acid oxidation and ketone bodies as the main source of energy production. CSCs have a remarkable ability to reprogram their metabolism in order to survive under adverse conditions such as hypoxia, acidosis, and starvation. There is increasing interest to identify molecular targets that can be utilized to kill CSCs and to control their growth. In this review, we discuss how an understanding of the unique metabolism of CSCs from different tumors can offer promising strategies for targeting CSCs and hence to prevent disease relapse and to treat the metasta...Continue Reading

References

Oct 1, 1976·Science·P C Nowell
Jul 6, 1992·Molecular and Cellular Biochemistry·M A MedinaI Núñez de Castro
Jun 23, 1972·Science·F MitelmanA Levan
Jul 1, 1982·Cell Biology International Reports·W L McKeehan
Dec 1, 1981·The American Journal of Medicine·D L DexterP Calabresi
May 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K SatoR L Veech
Mar 1, 1996·Clinical & Experimental Metastasis·R Martínez-ZaguilánM J Hendrix
Feb 24, 1997·Biochemical and Biophysical Research Communications·M B PaumenT Honjo
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·T MiyamotoK Akashi
Sep 25, 2001·IUBMB Life·R L VeechG F Cahill
Nov 2, 2001·Nature·T ReyaI L Weissman
Jun 28, 2002·The Journal of Biological Chemistry·Oliver E OwenRichard W Hanson
Jul 4, 2002·Cancer Investigation·William C CopelandJohn S Penta
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
May 27, 2003·Investigative Ophthalmology & Visual Science·Francesca Diomedi CamasseiRenata Boldrini
Mar 14, 1956·Annals of the New York Academy of Sciences·G KLEIN, E KLEIN
Jun 1, 1964·Journal of the National Cancer Institute·J M GRAY, G B PIERCE
Dec 31, 2003·Biochemical and Biophysical Research Communications·Xin Lin Zu, Michael Guppy
Apr 2, 2004·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Shin-ichi IshiokaRyuichi Kudo
Jul 13, 2004·Seminars in Cancer Biology·Fran Balkwill
Sep 25, 2004·Journal of Cellular Physiology·Maria L MachedaJames D Best
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Dec 21, 2004·Breast Cancer Research and Treatment·Valentina K TodorovaV Suzanne Klimberg
Dec 25, 2004·International Journal of Oral and Maxillofacial Surgery·Y ZhangG Yu
Apr 1, 2006·Journal of Cellular Physiology·Thomas LonerganBarry Bavister
Aug 8, 2006·Oncogene·M BrandonD C Wallace
Oct 31, 2006·Nature Cell Biology·Jong In YookStephen J Weiss
Feb 17, 2007·The FEBS Journal·Rafael Moreno-SánchezEmma Saavedra

❮ Previous
Next ❯

Citations

Sep 16, 2020·International Journal of Molecular Sciences·Jixian XiongLi Fu
Jan 29, 2021·Frontiers in Oncology·Dishari GhatakSusanta Roychoudhury
Feb 4, 2021·Cancer Immunology, Immunotherapy : CII·Varun Sasidharan NairEyad Elkord
Feb 7, 2021·Molecular Cancer·Longzheng XiaQianjin Liao
Dec 15, 2020·World Journal of Stem Cells·Xu Gao, Qiong-Zhu Dong
May 28, 2021·Journal of Theoretical Biology·Tagari Samanta, Sandip Kar
Jun 3, 2021·Cancers·Nuria Carmona-UleAna Belén Dávila-Ibáñez
Jul 3, 2021·Cells·Miguel Esperança-MartinsSérgio Dias
Jul 13, 2021·Frontiers in Oncology·Martina AddeoPellegrino Mazzone
Aug 23, 2021·Progress in Biophysics and Molecular Biology·Josephine WolfElizabeth M O'Day
Sep 8, 2021·Journal of Experimental & Clinical Cancer Research : CR·Hyunkoo KangBuHyun Youn
Sep 8, 2021·Aging·Francesco PacificoElvira Crescenzi
Jul 14, 2021·Molecular Cancer Therapeutics·Gabriel B MpillaAsfar S Azmi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
acetylation
chromosomal aberration
xenograft
flow cytometry
MDA

Software Mentioned

MSK
IMPACT
OxPhos

Related Concepts

Related Feeds

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Mengqi YangPeng Huang
Cellular and Molecular Life Sciences : CMLS
Hong QiuGaoliang Ouyang
Biochimica Et Biophysica Acta. Molecular Basis of Disease
Monish Ram MakenaArubala P Reddy
© 2021 Meta ULC. All rights reserved