Metabolic alteration in obese diabetes rats upon treatment with Centella asiatica extract

Journal of Ethnopharmacology
MaulidianiN H Lajis

Abstract

'Pegaga' is a traditional Malay remedy for a wide range of complaints. Among the 'pegaga', Centella asiatica has been used as a remedy for diabetes mellitus. Thus, we decided to validate this claim by evaluating the in vivo antidiabetic property of C. asiatica (CA) on T2DM rat model using the holistic (1)H NMR-based metabolomics approach. In this study, an obese diabetic (mimic of T2DM condition) animal model was developed using Sprague-Dawley rats fed with a high-fat diet and induced into diabetic condition by the treatment of a low dose of streptozotocin (STZ). The effect of C. asiatica extract on the experimental animals was followed based on the changes observed in the urinary and serum metabolites, measured by (1)H NMR of urine and blood samples collected over the test period. A long-term treatment of obese diabetic rats with CA extract could reverse the glucose and lipid levels, as well as the tricarboxylic acid cycle and amino acid metabolic disorders, back towards normal states. Biochemical analysis also showed an increase of insulin production in diabetic rats upon treatment of CA extract. This study has provided evidence that clearly supported the traditional use of CA as a remedy for diabetes. NMR-based metabolomics ...Continue Reading

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Citations

Jun 19, 2016·Journal of Pharmaceutical and Biomedical Analysis·Ahmed MedianiN H Lajis
Aug 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Tayyab AkhtarKhozirah Shaari
Aug 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leng Wei KhooFaridah Abas
Oct 3, 2019·Biomolecules·Bahare SalehiJavad Sharifi-Rad
Jul 28, 2020·Metabolites·Fatin Athirah PauziZulfitri Azuan Mat Daud
Jul 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qin ZhuHongyu Chen
Oct 6, 2020·Frontiers in Pharmacology·Boju SunTonghua Liu
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdul-Hamid EmwasMariusz Jaremko
May 26, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maede HasanpourMehrdad Iranshahi
Apr 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ayodeji B OyenihiBubuya Masola
Mar 5, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bubuya MasolaAyodeji B Oyenihi

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