Metabolic alterations in bladder cancer: applications for cancer imaging

Experimental Cell Research
Terry WhyardVictor Romanov

Abstract

Treatment planning, outcome and prognosis are strongly related to the adequate tumor staging for bladder cancer (BC). Unfortunately, a large discrepancy exists between the preoperative clinical and final pathologic staging. Therefore, an advanced imaging-based technique is crucial for adequate staging. Although Magnetic Resonance Imaging (MRI) is currently the best in vivo imaging technique for BC staging because of its excellent soft-tissue contrast and absence of ionizing radiation it lacks cancer-specificity. Tumor-specific positron emission tomography (PET), which is based on the Warburg effect (preferential uptake of glucose by cancer cells), exploits the radioactively-labeled glucose analogs, i.e., FDG. Although FDG-PET is highly cancer specific, it lacks resolution and contrast quality comparable with MRI. Chemical Exchange Saturation Transfer (CEST) MRI enables the detection of low concentrations of metabolites containing protons. BC is an attractive target for glucose CEST MRI because, in addition to the typical systemic administration, glucose might also be directly applied into the bladder to reduce toxicity-related complications. As a first stage of the development of a contrast-specific BC imaging technique we have...Continue Reading

References

May 1, 1973·International Journal of Cancer. Journal International Du Cancer·J BubeníkJ Donner
Jan 1, 1994·Urological Research·J L PetzoldtJ R Masters
Aug 17, 2002·Journal of Applied Physiology·Natalie Hiscock, Bente Klarlund Pedersen
Feb 24, 1956·Science·O WARBURG
Apr 7, 2005·Urologia Internationalis·Jee-Hyun LeeSung-Goo Chang
Sep 27, 2005·Journal of Biochemical and Biophysical Methods·Chenhui ZouZhufang Shen
Jul 4, 2007·The Journal of Cell Biology·Mariia YunevaYuri Lazebnik
Nov 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ralph J DeBerardinisCraig B Thompson
Jul 17, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Olivier Feron
Apr 22, 2011·Nature Reviews. Cancer·Willem H KoppenolChi V Dang
Jan 1, 2013·Journal of Magnetic Resonance·Elena VinogradovRobert E Lenkinski
Jan 11, 2013·NMR in Biomedicine·Guanshu LiuMichael T McMahon
Apr 12, 2013·BMC Medicine·Shaista Hafeez, Robert Huddart
Jul 9, 2013·Nature Medicine·Simon Walker-SamuelXavier Golay
Sep 21, 2013·Future Medicinal Chemistry·Michael J LukeyRichard A Cerione
May 23, 2014·AJR. American Journal of Roentgenology·Robbert J de HaasJurgen J Fütterer
Sep 23, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michal RivlinGil Navon
Oct 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao YangChangjun Yin

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Citations

Jul 20, 2016·Current Urology Reports·Cory M HugenSiamak Daneshmand
Aug 16, 2016·Biochemical and Biophysical Research Communications·Theodore G GabigVictor Romanov
Oct 11, 2016·Experimental Cell Research·Galina ReshetnikovaVictor Romanov
Nov 9, 2016·Clinical Nuclear Medicine·Luca TagliabueGiovanni Lucignani
Jan 19, 2020·Nature Reviews. Urology·Julieta AfonsoFátima Baltazar
May 30, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Masaki KobayashiYasuhisa Fujii
Oct 30, 2020·Frontiers in Oncology·Antoine GirardMathieu Rouanne
Apr 14, 2021·The Journal of Surgical Research·Peng-Yue ZhaoXiao-Hui Du

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