PMID: 518145Oct 1, 1979Paper

Metabolic alterations in human synovial lining cells in pigmented villonodular synovitis

Annals of the Rheumatic Diseases
B HendersonJ Chayen

Abstract

Synovial tissue from 3 patients with villonodular synovitis has been examined by quantitative cytochemistry. Considerable changes in the metabolism of the synoviocytes have been observed. These included a massive rise in the activity of glucose 6-phosphate dehydrogenase to levels even greater than those found in rheumatoid arthritis, and a significant rise in the activity of 2 glycolytic enzymes, glyceraldehyde 3-phosphate and lactate dehydrogenase. Lysosomal napthhylamidase showed raised activity with no latency. The sulphydryl content in the synoviocytes was raised, as was the amount of available phospholipid. This pattern of metabolic alterations is similar to that found in human rheumatoid synoviocytes.

References

Dec 1, 1978·Annals of the Rheumatic Diseases·B HendersonJ Chayen
Jul 17, 1975·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J T Dingle
Feb 1, 1979·Annals of the Rheumatic Diseases·B HendersonJ Chayen
Jan 1, 1978·Arthritis and Rheumatism·C L MainardiE D Harris
Feb 1, 1978·Annals of the Rheumatic Diseases·B HendersonJ Chayen
Sep 1, 1971·Annals of the Rheumatic Diseases·J Chayen, L Bitensky

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Citations

Jan 1, 1983·Progress in Histochemistry and Cytochemistry·B Henderson
Mar 26, 2016·Annals of the Rheumatic Diseases·M BinieckaU Fearon
Jul 1, 1984·Cell Biochemistry and Function·B Henderson
Aug 1, 1985·Seminars in Arthritis and Rheumatism·B Henderson, E R Pettipher

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