Metabolic alterations induce oxidative stress in diabetic and failing hearts: different pathways, same outcome

Antioxidants & Redox Signaling
David Roul, Fabio A Recchia

Abstract

Several authors have proposed a link between altered cardiac energy substrate metabolism and reactive oxygen species (ROS) generation. A cogent evidence of this association has been found in diabetic cardiomyopathy (dCM); however, experimental findings in animal models of heart failure (HF) and in human myocardium also seem to support the coexistence of the two alterations in HF. Two important questions remain open: whether pathological changes in metabolism play an important role in enhancing oxidative stress and whether there is a common pathway linking altered substrate utilization and activation of ROS-generating enzymes, independently of the underlying cardiac pathology. In this regard, the comparison between dCM and HF is intriguing, in that these pathological conditions display very different cardiac metabolic phenotypes. Our literature review on this topic indicates that a vast body of knowledge is now available documenting the relationship between the metabolism of energy substrates and ROS generation in dCM. In some cases, biochemical mechanisms have been identified. On the other hand, only a few and relatively recent studies have explored this phenomenon in HF and their conclusions are not consistent. Better methods ...Continue Reading

References

Oct 1, 1986·Biochemical Society Transactions·P J Randle
Feb 1, 1987·The Journal of Clinical Investigation·J A WisneskiM Mayr
Nov 1, 1985·The Journal of Clinical Investigation·J A WisneskiJ C Craig
Oct 1, 1994·Canadian Journal of Physiology and Pharmacology·G D Lopaschuk, J Gamble
Feb 1, 1994·Current Problems in Cardiology·H Taegtmeyer
Feb 15, 1997·European Journal of Biochemistry·J D McGarry, N F Brown
Jan 5, 1999·European Journal of Biochemistry·C DepréL Hue
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J SakamotoG D Lopaschuk
Jun 17, 2000·Biochimica Et Biophysica Acta·J Kerner, C Hoppel
Jul 11, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·L H YoungR R Russell
Oct 29, 2000·Experimental Gerontology·M D Brand
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D G Hardie, S A Hawley
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sanjay SrivastavaSumanth D Prabhu
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Feb 12, 2004·Pflügers Archiv : European journal of physiology·Joost J F P LuikenJan F C Glatz
Sep 18, 2004·Circulation Research·Janice M Huss, Daniel P Kelly
Dec 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Peipei WangJohn C Chatham
Jul 1, 2005·Physiological Reviews·William C StanleyGary D Lopaschuk
Jan 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Aimee LandarVictor M Darley-Usmar
May 13, 2006·The Journal of Physiology·Jason R B Dyck, Gary D Lopaschuk
Jul 11, 2006·Journal of Molecular and Cellular Cardiology·Sachin A GupteFabio A Recchia
Mar 16, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qinglin Yang, Yuhao Li
Oct 30, 2008·Cardiovascular Diabetology·Qing LiRavichandran Ramasamy
Dec 9, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ashwani MalhotraLeonard G Meggs
Nov 7, 2009·Journal of the American College of Cardiology·Ethan J AndersonP Darrell Neufer

❮ Previous
Next ❯

Citations

Sep 30, 2015·Canadian Journal of Physiology and Pharmacology·Thomas F WhayneNilanjana Maulik
Nov 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annia GalanoRussel J Reiter
Dec 3, 2016·Expert Review of Molecular Diagnostics·Harmen G BooijB Daan Westenbrink
May 6, 2020·British Journal of Pharmacology·Andrea Sorrentino, Thomas Michel
Dec 4, 2019·The American Journal of Chinese Medicine·Yonghui YuChenglong Wang
Mar 27, 2020·Frontiers in Physiology·Larissa VetterFelix T Kurz
May 26, 2018·International Journal of Vascular Medicine·Anderson Kiyoshi KagaAna Angélica Henrique Fernandes
Oct 2, 2019·Experimental and Therapeutic Medicine·Xiaodan ZhangWangen Li
Mar 7, 2020·Frontiers in Cardiovascular Medicine·Nina Kaludercic, Fabio Di Lisa
Dec 7, 2018·Frontiers in Cardiovascular Medicine·Marek Michalak, Luis B Agellon
Sep 27, 2018·International Journal of Molecular Sciences·Aleksandra DziubakJerzy Bełtowski
Apr 29, 2021·Journal of Inflammation Research·Ting-Ting ChenWu-Yi Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
MDA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.