Metabolic Alterations of Thyroid Cancer as Potential Therapeutic Targets

BioMed Research International
Domenico CiavardelliVeronica Vella

Abstract

Thyroid cancer (TC) is the most frequent endocrine tumor with a growing incidence worldwide. Besides the improvement of diagnosis, TC increasing incidence is probably due to environmental factors and lifestyle modifications. The actual diagnostic criteria for TC classification are based on fine needle biopsy (FNAB) and histological examination following thyroidectomy. Since in some cases it is not possible to make a proper diagnosis, classical approach needs to be supported by additional biomarkers. Recently, new emphasis has been given to the altered cellular metabolism of proliferating cancer cells which require high amount of glucose for energy production and macromolecules biosynthesis. Also TC displays alteration of energy metabolism orchestrated by oncogenes activation and tumor suppressors inactivation leading to abnormal proliferation. Furthermore, TC shows significant metabolic heterogeneity within the tumor microenvironment and metabolic coupling between cancer and stromal cells. In this review we focus on the current knowledge of metabolic alterations of TC and speculate that targeting TC metabolism may improve current therapeutic protocols for poorly differentiated TC. Future studies will further deepen the actual u...Continue Reading

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Citations

May 31, 2019·Scientific Reports·Laura FozzattiClaudia Gabriela Pellizas
Dec 6, 2018·International Journal of Molecular Sciences·Veronica Vella, Roberta Malaguarnera
Jun 5, 2020·Cell Communication and Signaling : CCS·Shabnam HeydarzadehMehdi Hedayati
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Fei ShenBo Xu
Aug 13, 2020·Oncology Letters·Guowu ZhangFang Liu

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Methods Mentioned

BETA
biopsy
GTPase
NMR

Software Mentioned

Metabolome
OxPhos

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