Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function

Annals of the New York Academy of Sciences
I-Chien WuMasashi Tanaka

Abstract

Mitochondria may play important roles in metabolic diseases, neurodegeneration, and aging. Therefore, noninvasive methods to assess mitochondrial metabolic function in humans are urgently needed. We demonstrated that the (13)C-breath test using [1-(13)C] acetate and [1-(13)C] pyruvate holds great potential for assessing the metabolic status in mitochondria. The (13)C-breath test allows us to assess dynamic metabolic pathways noninvasively within 60 min. This test will not only facilitate clinical evaluation of patients but also provide huge opportunities for further understanding of these conditions. The potential of the (13)C-breath test using (13)C-labeled pyruvate in humans cannot be overemphasized.

References

Jun 3, 1989·Lancet·A H SchapiraC D Marsden
Oct 11, 1974·Science·U Séquin, A I Scott
Oct 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D A Schoeller, E van Santen
Jun 4, 1981·Nature·J E Baldwin, H Krebs
Jan 1, 1993·Journal of Inherited Metabolic Disease·N GuffonP Guibaud
Jan 1, 1993·Annual Review of Nutrition·R H BehalM S Olson
Dec 1, 1996·The Biochemical Journal·S EatonM Pourfarzam
Aug 10, 2000·The American Journal of Pathology·L J HsuE Masliah
Jan 21, 2001·The Journal of Biological Chemistry·T FujinoT T Yamamoto
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·E KirchesK Dietzmann
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Hirohito SoneNobuhiro Yamada
Jan 26, 2002·Human Molecular Genetics·Michael T LinM Flint Beal
Feb 28, 2002·Nature Genetics·Ian P M TomlinsonUNKNOWN Multiple Leiomyoma Consortium
May 10, 2002·The New England Journal of Medicine·Hartmut P H NeumannUNKNOWN Freiburg-Warsaw-Columbus Pheochromocytoma Study Group
Sep 13, 2002·The New England Journal of Medicine·James A Strauchen
Mar 1, 2003·Diabetes Care·Paul HoganUNKNOWN American Diabetes Association
Aug 20, 2003·Archives of Neurology·Liesi E HebertDenis A Evans
May 1, 1955·Journal of Applied Physiology·N LIFSONR McCLINTOCK
Feb 13, 2004·The New England Journal of Medicine·Kitt Falk PetersenGerald I Shulman
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin R ShortK Sreekumaran Nair

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Citations

Oct 25, 2013·Science Translational Medicine·Gopinath Sutendra, Evangelos D Michelakis
Dec 3, 2010·American Journal of Physiology. Cell Physiology·William W Wheaton, Navdeep S Chandel
Feb 3, 2011·The Journal of Clinical Investigation·Ignacio Munoz-Sanjuan, Gillian P Bates

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