Metabolic and endocrine responses to cold exposure in chronically incubated extrauterine goat fetuses

Pediatric Research
N UnnoY Taketani

Abstract

To investigate developmental aspects of metabolic and endocrine responses to cold exposure in fetuses, we conducted experiments on six goat fetuses, three aged 95-116 d of gestation (dGA; group I), and three aged 122-134 dGA (group II), using an extrauterine fetal incubation system that provided arterio-venous extracorporeal membrane oxygenation (A-V ECMO). The fetuses were cannulated via the umbilical vessels, and their blood gas exchange was totally supported by A-V ECMO, while they were maintained in an isothermal incubator containing artificial amniotic fluid. After confirming that fetuses were in metabolically stable condition in the extrauterine incubation system, fetal core temperature was lowered by 2 degrees C over 2 h by decreasing the temperature of incubating fluid from 39.5 degrees C. During and after cold exposure, fetal heart rate and arterial blood pressure remained unchanged. We observed significant increases in oxygen consumption and plasma concentrations of norepinephrine, epinephrine, adrenocorticotropic hormone, and cortisol in group II but not in group I fetuses. In addition, based on regression analysis, maximal changes of these parameters during cold exposure were linearly correlated with gestational age...Continue Reading

References

Aug 1, 1992·The Proceedings of the Nutrition Society·M E Symonds, M A Lomax
Dec 1, 1991·Pediatric Research·T R GunnP D Gluckman
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
May 1, 1990·Canadian Journal of Physiology and Pharmacology·K Akagi, J R Challis
Feb 1, 1989·Artificial Organs·G Beaudoin, M Y Jaffrin
May 1, 1989·The American Journal of Physiology·G K IwamotoG W Hunninghake
Jan 1, 1974·Gynecologic Investigation·T A StandaertW A Hodson
Sep 1, 1968·The Journal of Physiology·G Alexander, D Williams
Oct 1, 1983·The Journal of Physiology·P D GluckmanB M Johnston
Apr 1, 1983·American Journal of Obstetrics and Gynecology·J ItskovitzA M Rudolph
Aug 1, 1994·American Journal of Obstetrics and Gynecology·K FujimoriY Murata
Dec 1, 1996·Journal of Applied Physiology·K T BallG G Power
Mar 1, 1997·Artificial Organs·D N RushtonA M Tromans

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Citations

Oct 23, 2012·Gynécologie, obstétrique & fertilité·P Chavatte-PalmerP Boileau
Mar 16, 2011·Annals of the New York Academy of Sciences·Carlo BullettiDominique de Ziegler
Jan 18, 2002·Journal of Applied Physiology·Helen P LaburnDuncan Mitchell

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