Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

Immunity
Anthony T PhanChristopher K Glass

Abstract

Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of cellular processes to promote effective resolution of infection. To accommodate increased bioenergetic and biosynthetic demands, metabolic pathways are harnessed to maximize proliferation and effector molecule production. In parallel, activation initiates context-specific gene-expression programs that drive effector functions and cell fates that correlate with changes in epigenetic landscapes. Many chromatin- and DNA-modifying enzymes make use of substrates and cofactors that are intermediates of metabolic pathways, providing potential cross talk between metabolism and epigenetic regulation of gene expression. In this review, we discuss recent studies of T cells and macrophages supporting a role for metabolic activity in integrating environmental signals with activation-induced gene-expression programs through modulation of the epigenome and speculate as to how this may influence context-specific macrophage and T cell responses to infection.

Citations

Feb 13, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S AspeslaghS Postel-Vinay
Dec 8, 2017·Frontiers in Immunology·Scott M Seki, Alban Gaultier
Oct 24, 2017·Nature Cell Biology·Michael A ReidJason W Locasale
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·David A HillMitchell A Lazar
Nov 10, 2017·Current Rheumatology Reports·Naomi I Maria, Anne Davidson
May 13, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew R DiNardoGeorge Makedonas
Dec 31, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muyao GuoChristopher D Scharer
Aug 30, 2018·Physiological Reviews·Vanessa Frodermann, Matthias Nahrendorf
Jun 9, 2018·Circulation Research·Alena GrebeEicke Latz
Nov 23, 2018·The Journal of Experimental Medicine·Wen ZhangYun-Cai Liu
Feb 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eleftheria IeronymakiChristos Tsatsanis
Jan 13, 2018·Science·Amanda N HenningNicholas P Restifo
Mar 29, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Calvin C ChanSenad Divanovic
Oct 31, 2017·Cellular & Molecular Immunology·Xiaomin ZhangXuetao Cao
May 28, 2019·Immunology and Cell Biology·David O'Sullivan
Oct 28, 2019·International Journal of Molecular Sciences·Beatriz Herrero-FernandezJose Maria Gonzalez-Granado
Sep 1, 2017·Current Opinion in Lipidology·Charles ThomasDavid Masson
Aug 15, 2017·Current Opinion in Hematology·Lyla A Youssef, Steven L Spitalnik
Apr 8, 2020·The FEBS Journal·Gonzalo Soto-HerederoMaría Mittelbrunn
Mar 19, 2020·Parasite Immunology·Jeongho Park, Christopher A Hunter
Jul 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ye ZhangXianjing Li
Apr 14, 2020·Journal of Alzheimer's Disease : JAD·Jing JinZhao-Ming Ge
Sep 18, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Miguel Ángel Medina
Sep 27, 2019·Nature Communications·Tao YuYichuan Xiao
Aug 9, 2017·Frontiers in Immunology·Tarcio Teodoro BragaNiels Olsen Saraiva Camara
Mar 30, 2018·Frontiers in Immunology·Jaydeep BhatDieter Kabelitz
Aug 19, 2018·Nature Communications·David MartinoRichard Saffery
May 14, 2019·The Journal of Clinical Investigation·Benjamin D Singer, Navdeep S Chandel
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Huan LuXinbo Wu
Apr 3, 2020·International Journal of Molecular Sciences·Yunhui Jia, Yuanyuan Wei
Apr 3, 2020·Immunological Reviews·Peter J McGuire
Apr 24, 2020·Frontiers in Physiology·Dharanidhar DangDebashis Sahoo
Jul 8, 2020·Nature Immunology·Tobias WolfRoger Geiger
Jul 24, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Lizhe Sun (孙李哲)Hong Wang (王虹)
Jul 21, 2017·Frontiers in Endocrinology·Sarah-Maria Fendt
Aug 7, 2017·F1000Research·Michael J GarabedianFreddy Jeanneteau
Oct 4, 2017·Seminars in Immunopathology·Laszlo GrohNiels P Riksen
Dec 21, 2018·Frontiers in Immunology·Dmitry NamgaladzeBernhard Brüne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.