PMID: 6102914Feb 1, 1980

Metabolic and haemodynamic effects and pharmacokinetics of a new selective beta 1-adrenoceptor agonist, prenalterol, in man

European Journal of Clinical Pharmacology
O RönnL Svensson

Abstract

The metabolic and haemodynamic effects of three intravenous doses (0.5, 1.0 and 4.0 mg) of prenalterol, a selective beta 1-adrenoceptor agonist, were studied in 10 healthy male subjects. Plasma levels of prenalterol during the experiments were related to the haemodynamic effects. Prenalterol induced a dose-dependent increase in systolic blood pressure and heart rate. The maximal effects amounted to about 30 mm Hg and 15 beats/min, respectively, after the highest dose (4.0 mg). The diastolic blood pressure fell by a maximum of about 15 mm Hg. The effect of prenalterol on systolic blood pressure and heart rate persisted for about 3 h after the end of the last infusion, whereas that on diastolic blood pressure only lasted for 60 min. Compared with placebo, there was a moderate increase in plasma FFA and glycerol. A small rise in insulin level was also recorded, but no significant change was seen in other metabolic variables--triglycerides, glucose, lactate pyruvate. Serum potassium tended to decrease and serum sodium was unchanged. The initial distribution of prenalterol was rapid (half-life 7 min) and the overall elimination rate corresponded to a plasma half-life of 2 h. A linear relationship was found between the plasma level o...Continue Reading

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Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·E J SainsburyJ J Ashley
Jan 1, 1981·European Journal of Clinical Pharmacology·C GraffnerO Rönn
Nov 1, 1980·European Journal of Clinical Pharmacology·A WeissU C Dubach
Jan 1, 1982·Pharmacology & Therapeutics·D B EvansH R Kaplan
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
May 10, 1980·Lancet·B Jones
Jan 1, 1993·British Journal of Clinical Pharmacology·C A HaffnerB Hughes
Feb 1, 1991·Journal of Clinical Pharmacy and Therapeutics·M J KendallB A Hughes
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·A BranziB Magnani
Mar 1, 1986·Gut·E Lyrenäs, H Abrahamsson
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Related Concepts

Adrenergic beta-Agonists
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H-80-62

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