Metabolic and hemodynamic activation of postischemic rat brain by cortical spreading depression

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
M Kocher

Abstract

Following transient ischemia of the brain, the coupling between somatosensory activation and the hemodynamic-metabolic response is abolished for a certain period despite the partial recovery of somatosensory evoked responses. To determine whether this disturbance is due to alterations of the stimulus-induced neuronal excitation or to a breakdown of the coupling mechanisms, cortical spreading depression was used as a metabolic stimulus in rats before and after ischemia. Adult rats were subjected to 30 min of global forebrain ischemia and 3-6 h of recirculation. EEG, cortical direct current (DC) potential, and laser-Doppler flow were continuously recorded. Local CBF (LCBF), local CMRglc (LCMRglc), regional tissue contents of ATP, glucose, and lactate, and regional pH were determined by quantitative autoradiography, substrate-induced bioluminescence, and fluorometry. Amplitude and frequency of the DC shifts did not differ between groups. In control animals, spreading depression induced a 77% rise in cortical glucose consumption, a 66% rise in lactate content, and a drop in tissue pH of 0.3 unit. ATP and glucose contents were not depleted. During the passage of DC shifts, transient increases (less than 2 min) in laser-Doppler flow ...Continue Reading

References

Mar 1, 1978·The American Journal of Physiology·T J HougenT W Smith
May 15, 1979·Pflügers Archiv : European journal of physiology·E Leniger-Follert, K A Hossmann
Jul 1, 1975·Journal of Neurophysiology·E SugayaY Noda
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·R Schmidt-KastnerK A Hossmann
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M UekiK A Hossmann
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·D J Combs, L G D'Alecy
May 1, 1986·Stroke; a Journal of Cerebral Circulation·H MabeM Ohno
Aug 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D DietrichR Busto
Mar 1, 1986·Stroke; a Journal of Cerebral Circulation·J GrottaD Hunter
Dec 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W Paschen
Feb 28, 1973·Brain Research·D A PrinceE Neher
Nov 1, 1973·Journal of Neurochemistry·U PonténB K Siesjö
Dec 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Lauritzen
Mar 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W A Mutch, A J Hansen
May 1, 1983·Journal of Neurochemistry·W A Pulsinelli, T E Duffy
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Jan 1, 1982·Neuroscience·C R Ferreira-Filho, H Martins-Ferreira
Nov 1, 1982·Annals of Neurology·M LauritzenA J Hansen
Oct 1, 1981·Journal of Neurochemistry·A GjeddeB Quistorff
Dec 1, 1981·Acta Physiologica Scandinavica·A J Hansen, T Zeuthen

❮ Previous
Next ❯

Citations

Oct 1, 1994·Annals of Neurology·K A Hossmann
Feb 1, 1996·Progress in Neurobiology·H J Luhmann
Jan 10, 1998·European Journal of Pharmacology·D K SchellerF Tegtmeier
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Fabricius, M Lauritzen
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J RötherM E Mosley
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K MatsushimaA M Hakim
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E BuschK A Hossmann
May 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T ElsM Moseley
Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B SchmitzK A Hossmann
Sep 18, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A de CrespignyM E Moseley
Aug 27, 2014·Brain : a Journal of Neurology·Jason M HinzmanJed A Hartings
Apr 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andre SauterMarkus Rudin
Jan 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Miyuki UnekawaNorihiro Suzuki
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A KastrupA de Crespigny
Oct 14, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Miyuki UnekawaNorihiro Suzuki
Jun 30, 2001·Brain Research·A GorjiE J Speckmann
Feb 5, 2004·Brain Research·Warren R SelmanRobert A Ratcheson
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T IijimaK A Hossmann
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N C SinghE M Nemoto
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G MiesK A Hossmann
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K AdachiG A Dienel
Mar 5, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Miyuki UnekawaNorihiro Suzuki
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BackK A Hossmann
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Q ChenH Chen
Apr 17, 2003·British Medical Bulletin·Mark F LythgoeNeil G Harris
Feb 1, 1994·Stroke; a Journal of Cerebral Circulation·T BackK A Hossmann
Mar 20, 1998·Stroke; a Journal of Cerebral Circulation·T Kristián, B K Siesjö
Sep 20, 2017·Current Neuropharmacology·Yağmur Çetin TaşYasemin Gürsoy-Özdemir
Jul 3, 2015·Physiological Reviews·Cenk Ayata, Martin Lauritzen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
T BackK A Hossmann
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
T IijimaK A Hossmann
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
A Mayevsky, H R Weiss
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
G MiesK A Hossmann
© 2021 Meta ULC. All rights reserved