PMID: 1317418Jun 1, 1992

Metabolic and histologic investigation of the nature of nephrocalcinosis in children with hypophosphatemic rickets and in the Hyp mouse

The Journal of Pediatrics
U AlonD J Harris

Abstract

To investigate the biochemical nature of nephrocalcinosis in children with hypophosphatemic rickets treated with orally administered phosphate and vitamin D, we studied five such patients, aged 3.7 to 12.3 years, during treatment and again 3 days after it had been discontinued. Treatment was associated with significant increases in mean serum phosphate concentration and urine phosphate/creatinine ratio, from 0.71 to 1.03 mmol/L and from 3.61 to 9.42 mmol/mmol, respectively. Significant correlation was found between urine phosphate/creatinine and oxalate/creatinine ratios (r = 0.670; p less than 0.01); however, the mean urine oxalate/creatinine ratio of 65.0 mumol/mmol while patients were taking phosphate orally was not significantly different from the ratio of 59.0 mumol/mmol when treatment was discontinued. Kidney biopsy specimens from three of the patients showed that the renal calcifications were located mainly intratubularly and were composed exclusively of calcium phosphate. In a further investigation of the nature of phosphate-induced nephrocalcinosis, six 6-week-old male Hyp mice, the murine analog of the human disease, received oral phosphate therapy with drinking water for 48 days; six others served as control animals....Continue Reading

References

Apr 1, 1991·Archives of Disease in Childhood·T M BarrattG A Rose
Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E P LeumannA Matasovic
Nov 1, 1987·The Journal of Pediatrics·P R GoodyerC R Scriver
Mar 1, 1982·Calcified Tissue International·P J MarieF H Glorieux
May 1, 1984·Kidney International·J I ScheinmanS M Mauer
Jan 1, 1958·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M McGEE-RUSSELL
May 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P PIZZOLATO
Feb 28, 1935·The Journal of Experimental Medicine·E M Mackay, J Oliver

Citations

Feb 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M A SaleemM H Winterborn
Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A TaylorM E Norman
Aug 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D S TheodoropoulosW A Gahl
Dec 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·K LattaJ C Chan
Jun 24, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ari Auron, U S Alon
Oct 28, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Helena Vaisbich, Vera H Koch
Nov 22, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine QuinlanAoife M Waters
Feb 22, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jyothsna Gattineni, Michel Baum
Mar 18, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Glen S MarkowitzVivette D D'Agati
Feb 1, 1995·Clinical Endocrinology·J KnudtzonG Sødal
Feb 8, 2008·Clinical Journal of the American Society of Nephrology : CJASN·U S AlonL Darryl Quarles
May 3, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Goretti M G Penido, U S Alon
Sep 9, 2008·European Journal of Endocrinology·Helge RaederRobert Bjerknes
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·V A LuyckxA S Yu
Sep 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michel BaumRaymond Quigley
Oct 16, 2008·The American Journal of the Medical Sciences·Yaacov OriAsher Korzets
Jun 13, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N AgrawalC P Thomas
Jun 10, 2004·Human Pathology·Glen S MarkowitzVivette D D'Agati
Jul 24, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Melikşah KeskinZehra Aycan
Apr 20, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Diana OvejeroMichael T Collins
Apr 28, 2017·PloS One·Yuwen LiClemens Bergwitz
Oct 13, 2012·Human & Experimental Toxicology·C C WillhiteV S Bhat
Oct 28, 2016·American Journal of Physiology. Renal Physiology·Daniel CaballeroClemens Bergwitz
Sep 30, 2005·Journal of the American Society of Nephrology : JASN·Glen S MarkowitzVivette D D'Agati
Jul 4, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Eliot C HeherBenjamin D Humphreys
Apr 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·U S AlonM A Nichols
Mar 1, 1993·Acta Paediatrica. Supplement·C F VergeM Silink
Feb 28, 2019·Orphanet Journal of Rare Diseases·Signe Sparre Beck-NielsenOuti Mäkitie
May 1, 1996·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·F C McCormickC E Keen

Related Concepts

Calcium phosphate
Bio-Base
Monetite
Tetracalcium Phosphate
Calcium phosphate, monobasic, anhydrous
Metazoa
Soltriol
Calcium Phosphates
Phosphate Diabetes
Kidney

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.