Abstract
Eosinophilic meningitis is a disease characterized by increased eosinophils in the cerebrospinal fluid (CSF), which is the most commonly caused by invasion of the central nervous system by helminths, as occurs in Angiostrongylus cantonensis infections. The rodent Rattus norvegicus is the definitive natural host and humans act as accidental hosts and can become infected by eating raw or undercooked snails or food contaminated with infective L3 larvae. Recently in Brazil there have been four cases of eosinophilic meningitis due to ingestion of infected Achatina fulica. To evaluate biochemical and histopathological changes caused by this parasite, R. norvegicus were experimentally infected with 100 L3 larvae of A. cantonensis. After the anesthetic procedure, serum from the rodents was collected from the inferior vena cava for evaluation of the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALKP), gamma-glutamyl transferase (GGT), total protein and its fractions. During the necropsy, the liver was collected and weighed. Then a 1-g fragment was extracted from the major lobe to quantify the hepatic glycogen and fragment remainder was taken from the same lobe and fixed in Milloning's ...Continue Reading
References
Oct 1, 1979·The Journal of Infectious Diseases·E R Moxon, P Anderson
Dec 1, 1979·Neurology·T Kuberski, G D Wallace
Jan 1, 1965·Advances in Parasitology·J E Alicata
Oct 22, 1998·The New England Journal of Medicine·M TraunerJ L Boyer
Feb 24, 2005·Veterinary Parasitology·M C CuryJ M B Baptista
May 25, 2005·Veterinary Immunology and Immunopathology·O TimoteoJ R Espinoza
Feb 15, 2007·The Journal of Antimicrobial Chemotherapy·Ke-Min Chen, Shih-Chan Lai
Dec 21, 2007·Memórias do Instituto Oswaldo Cruz·Roberta Lima CaldeiraOmar dos Santos Carvalho
Oct 17, 2008·The Lancet Infectious Diseases·Qiao-Ping WangZhao-Rong Lun
Apr 16, 2009·Clinical Microbiology Reviews·Carlos Graeff-TeixeiraKentaro Yoshimura
Aug 13, 2009·Veterinary Parasitology·K P Lan, S C Lai
Jan 14, 2010·Arquivos de neuro-psiquiatria·Ana Rosa Melo Correa LimaMaria Lúcia Brito Ferreira
Feb 6, 2010·Parasitology Research·R EdithM B Thilagar
Jan 25, 2011·Veterinary Parasitology·Juberlan S GarciaJairo Pinheiro
Sep 15, 2011·Revista Do Instituto De Medicina Tropical De São Paulo·José Luis QuirósYendry Jiménez
Jul 11, 2012·Parasitology Research·Lisi OuYangWanlong Lei
Sep 20, 2012·Memórias do Instituto Oswaldo Cruz·Omar Dos Santos CarvalhoRoberta Lima Caldeira
Apr 9, 2013·Revista Do Instituto De Medicina Tropical De São Paulo·Maria Cristina Carvalho do Espírito-SantoRonaldo César Borges Gryschek