Metabolic and Hypertensive Complications of Pregnancy in Women with Nephrolithiasis

Clinical Journal of the American Society of Nephrology : CJASN
Jessica Sheehan TangrenRavi Thadhani

Abstract

Kidney stones are associated with future development of hypertension, diabetes, and the metabolic syndrome. Our objective was to assess whether stone formation before pregnancy was associated with metabolic and hypertensive complications in pregnancy. We hypothesized that stone formation is a marker of metabolic disease and would be associated with higher risk for maternal complications in pregnancy. We conducted a retrospective cohort study of women who delivered infants at the Massachusetts General Hospital from 2006 to 2015. Women with abdominal imaging (computed tomography or ultrasound) before pregnancy were included in the analysis. Pregnancy outcomes in women with documented kidney stones on imaging (stone formers, n=166) were compared with those of women without stones on imaging (controls, n=1264). Women with preexisting CKD, hypertension, and diabetes were excluded. Gestational diabetes and preeclampsia were more common in stone formers than nonstone formers (18% versus 6%, respectively; P<0.001 and 16% versus 8%, respectively; P=0.002). After multivariable adjustment, previous nephrolithiasis was associated with higher risks of gestational diabetes (adjusted odds ratio, 3.1; 95% confidence interval, 1.8 to 5.3) and p...Continue Reading

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Citations

Aug 19, 2020·Journal of Perinatal Medicine·Emily K ClennonAaron B Caughey
Feb 6, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Abirami KirubarajanRoger Buckley
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Apr 20, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Charat ThongprayoonAndrew D Rule
May 14, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Natasha SebastianHaim Arie Abenhaim

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