Metabolic and immunologic control of intestinal cell function by mTOR

International Immunology
Stephanie D Fritsch, Thomas Weichhart

Abstract

The intestinal epithelium is one of the most quickly dividing tissues in our body, combining the absorptive advantages of a single layer with the protection of a constantly renewing barrier. It is continuously exposed to nutrients and commensal bacteria as well as microbial and host-derived metabolites, but also to hazards such as pathogenic bacteria and toxins. These environmental cues are sensed by the mucosa and a vast repertory of immune cells, especially macrophages. A disruption of intestinal homeostasis in terms of barrier interruption can lead to inflammatory bowel diseases and colorectal cancer, and macrophages have an important role in restoring epithelial function following injury. The mammalian/mechanistic target of rapamycin (mTOR) signalling pathway senses environmental cues and integrates metabolic responses. It has emerged as an important regulator of intestinal functions in homeostasis and disease. In this review, we are going to discuss intestinal mTOR signalling and metabolic regulation in different intestinal cell populations with a special focus on immune cells and their actions on intestinal function.

References

Feb 1, 1992·Transplantation·A FrancavillaS L Schreiber
Nov 1, 1990·The New England Journal of Medicine·A EkbomH O Adami
Apr 29, 2004·Transplantation·Phuong-Thu T PhamAlan H Wilkinson
Dec 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sarah L PullThaddeus S Stappenbeck
Aug 3, 2006·Nature Reviews. Drug Discovery·Sandrine FaivreEric Raymond
May 15, 2007·Lancet·Enrico FlossmannUNKNOWN British Doctors Aspirin Trial and the UK-TIA Aspirin Trial
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
May 24, 2008·The Journal of Clinical Investigation·Nobuhiko KamadaToshifumi Hibi
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Teruaki FujishitaMakoto M Taketo
Oct 14, 2008·Immunity·Thomas WeichhartMarcus D Säemann
Oct 9, 2009·Journal of Cell Science·Mathieu Laplante, David M Sabatini
Nov 6, 2009·The New England Journal of Medicine·Erik-Oliver GlockerChristoph Klein
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Apr 28, 2010·Gastroenterology·Janos TerzićMichael Karin
Jan 25, 2011·Nature Cell Biology·Joungmok KimKun-Liang Guan
Apr 27, 2011·The American Journal of Gastroenterology·Bernadette BegueFrank M Ruemmele
Jun 15, 2011·Cell Cycle·Won Jun Oh, Estela Jacinto
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Oksana B SerebrennikovaPhilip N Tsichlis
Apr 17, 2012·Cell·Mathieu Laplante, David M Sabatini
Apr 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masashi OhtaniSatoshi Matsuda
May 3, 2012·Inflammatory Bowel Diseases·Christopher J MoranAleixo M Muise
May 29, 2012·Current Pharmaceutical Design·Sofía García-MauriñoCecilia Domínguez
Jul 20, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Oct 11, 2012·Nature Communications·Namiko HoshiRuslan Medzhitov
Jan 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karl KatholnigThomas Weichhart
Jan 16, 2013·Current Opinion in Genetics & Development·Marion CornuMichael N Hall
Jan 17, 2013·The Journal of Clinical Investigation·Stefan ThiemMatthias Ernst
Mar 29, 2013·Nature·G M TannahillL A J O'Neill
Nov 15, 2013·Lancet·Hermann BrennerChristian Peter Pox
Jan 8, 2014·Oncotarget·Maria Giovanna Francipane, Eric Lagasse
Feb 11, 2014·Current Protocols in Immunology·Benoit ChassaingMatam Vijay-Kumar
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Mitsugu Shimobayashi, Michael N Hall
Apr 26, 2014·World Journal of Gastroenterology : WJG·Xiao-Wen Wang, Yan-Jie Zhang
Apr 29, 2014·Developmental Cell·Alejo EfeyanDavid M Sabatini

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