Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Krisztina MarosiMark P Mattson

Abstract

Evolutionary considerations suggest that the body has been optimized to perform at a high level in the food-deprived state when fatty acids and their ketone metabolites are a major fuel source for muscle cells. Because controlled food deprivation in laboratory animals and intermittent energy restriction in humans is a potent physiologic stimulus for ketosis, we designed a study to determine the impact of intermittent food deprivation during endurance training on performance and to elucidate the underlying cellular and molecular mechanisms. Male mice were randomly assigned to either ad libitum feeding or alternate-day food deprivation (ADF) groups, and half of the mice in each diet group were trained daily on a treadmill for 1 mo. A run to exhaustion endurance test performed at the end of the training period revealed superior performance in the mice maintained on ADF during training compared to mice fed ad libitum during training. Maximal O2 consumption was increased similarly by treadmill training in mice on ADF or ad libitum diets, whereas respiratory exchange ratio was reduced in ADF mice on food-deprivation days and during running. Analyses of gene expression in liver and soleus tissues, and metabolomics analysis of blood su...Continue Reading

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Mar 7, 2019·Biology Open·Aileen RivellPamela J Yao
Jul 10, 2019·Current Sports Medicine Reports·Emily Levy, Thomas Chu
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Dec 2, 2020·Biology·Junko NakaiEtsuro Ito
Aug 17, 2020·Medicine and Science in Sports and Exercise·Aidan J BradyBrendan Egan

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