PMID: 8992606Mar 1, 1996Paper

Metabolic and morphometric changes in small and large intestine in rats fed high-fiber diets

Toxicologic Pathology
A StarkZ Madar

Abstract

Structural modifications of the intestine following fiber intake may play an important role in the physiological effects induced by dietary fiber. The aim of this study was to examine possible mechanisms for the hypocholesterolemic effects of dietary fibers by evaluating both biochemical and morphometric parameters. Thirty male Sprague-Dawley rats were divided into 3 groups and fed either a fiber-free, 15% fiber high methoxy pectin, or 15% cellulose diet for a 4-wk period. Plasma cholesterol levels, hepatic enzyme activity, and fecal bile acid excretion were determined, and changes in the intestinal structure were evaluated. Daily fecal bile acid excretion was significantly higher in rats fed the pectin diet accompanied by elevated HMG-CoA reductase activity. Pectin feeding led to significant elongation of both the small and large intestine whereas cellulose only affected colon length. Computerized image analysis of intestinal cross-sections showed enlarged muscle area in the ileum and midcolon of pectin-fed rats and greater mucosal area in the colon. Circular muscle cell hypertrophy was also observed in the colon length. Computerized image analysis of intestinal cross-sections showed enlarged muscle area in the ileum and midco...Continue Reading

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Citations

Jul 3, 1998·Critical Reviews in Oncology/hematology·M A MooreH Tsuda
Jan 27, 2015·Digestive Diseases and Sciences·Glen S PattenMichael A Conlon
Apr 21, 1998·Toxicologic Pathology·J E BurkhardtR Ochoa
May 11, 2006·Immunopharmacology and Immunotoxicology·Sergey V PopovYury S Ovodov
May 9, 2015·World Journal of Gastroenterology : WJG·Sung-Eun KimMi-Kyung Sung

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