Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts.

ELife
Ruihua MaBeatriz Sosa-Pineda

Abstract

The distribution of complementary metabolic functions in hepatocytes along a portocentral axis is called liver zonation. Endothelial secreted Wnt ligands maintain metabolic zonation in the adult murine liver but whether those ligands are necessary to initiate zonation in the immature liver has been only partially explored. Also, numerous non-metabolic proteins display zonated expression in the adult liver but it is not entirely clear if their localization requires endothelial Wnts. Here we used a novel transgenic mouse model to compare the spatial distribution of zonated non-metabolic proteins with that of typical zonated metabolic enzymes during liver maturation and after acute injury induced by carbon tetrachloride (CCl4). We also investigated how preventing Wnt ligand secretion from endothelial cells affects zonation patterns under homeostasis and after acute injury. Our study demonstrates that metabolic and non-metabolic zonation are established non-synchronously during maturation and regeneration and require multiple endothelial Wnt sources.

References

Jul 1, 1989·Physiological Reviews·K Jungermann, N Katz
Dec 31, 1997·Microscopy Research and Technique·R G NotenboomW H Lamers
Mar 25, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shigeki SekineMatthias Hebrok
Jun 3, 2006·Developmental Cell·Samira BenhamoucheSabine Colnot
Jan 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Timo H-W LüdtkeAndreas Kispert
Dec 23, 2009·The Journal of Experimental Medicine·Trung H M PhamJason G Cyster
Jul 9, 2010·Genesis : the Journal of Genetics and Development·April C CarpenterRichard A Lang
Aug 20, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tzu-Hsuan YehJaideep Behari
Jun 18, 2011·Gastroenterology·Nadja LehwaldKarl G Sylvester
Apr 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jing YangSatdarshan P Monga
Jul 16, 2014·World Journal of Gastroenterology : WJG·Rolf Gebhardt, Madlen Matz-Soja
Dec 15, 2015·Cell Reports·Ana Sofia RochaAndreas Schedl
Apr 19, 2016·Nature Cell Biology·Lara Planas-PazJan S Tchorz
Nov 20, 2016·Nature Communications·Wenjuan PuBin Zhou
Oct 24, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas LeibingPhilipp-Sebastian Koch
Oct 18, 2016·Inflammation and Regeneration·Minoru Tanaka, Atsushi Miyajima
Jan 11, 2018·Journal of Cellular Physiology·Abbas Shapouri-MoghaddamAmirhossein Sahebkar
Feb 11, 2018·Scientific Reports·Zoë D BurkeDavid Tosh
Sep 18, 2018·Nature Biotechnology·Keren Bahar HalpernShalev Itzkovitz
Feb 15, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ludan ZhaoRoel Nusse
Dec 24, 2019·Cell Stem Cell·Feng ChenHolger Willenbring

❮ Previous
Next ❯

Citations

Sep 3, 2020·International Journal of Molecular Sciences·Wolfgang KreiselPeter Deibert
Nov 3, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ki M Mak, Da Wi Shin
Jan 13, 2021·Nature Metabolism·Stefano Annunziato, Jan S Tchorz
Mar 22, 2021·Angiogenesis·Philipp-Sebastian KochHellmut G Augustin
Aug 8, 2021·International Journal of Molecular Sciences·Mattia PasquaMaria Giovanna Francipane
May 14, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·David S UmbaughHartmut Jaeschke
Aug 27, 2021·Metabolites·Blandine TramuntWalter Wahli

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
Assay
PCR

Software Mentioned

Adobe Photoshop CC
Photoshop CC
GraphPad Prism
Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seikagaku. The Journal of Japanese Biochemical Society
H Ogawa, S Kawamata
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K Jungermann, Thomas Kietzmann
© 2021 Meta ULC. All rights reserved