Abstract
Hypertensive patients with normal glucose tolerance (NGT) but 1-h post-load plasma glucose ≥ 155 mg/dl (1-h high), during an oral glucose tolerance test (OGTT), show higher insulin resistance and multiple target organ damages. Experimental and clinical studies demonstrate that silybin presents anti-inflammatory and metabolic effects, improving insulin resistance and endothelial dysfunction. This study aims to evaluate the effects of the complex silybin-vitamin E and phospholipids on inflammatory, metabolic and vascular parameters in NGT 1-h high hypertensive patients. This is a pilot, single arm, interventional, longitudinal study enrolling 50 Caucasian NGT 1-h high hypertensive outpatients, 27 men and 23 women, age range 42-60 years (mean + SD = 52 ± 7). After 6 months of silybin intake, there is a significant improvement in metabolic profile. The glucose response during OGTT significantly improves (AUCglucose0-120 309.6 ± 63.4 at baseline vs 254.6 ± 35.5 at the follow-up, ∆ = - 55, 95% CI from - 67 to - 43, p < 0.0001), so as insulin response (AUCinsulin0-120 238.2 ± 99.1 vs 159.3 ± 44.9, ∆ = - 78.9, 95% CI from - 100.0 to - 57.8, p < 0.0001), in accordance with the increase of insulin sensitivity index Matsuda. Silybin intak...Continue Reading
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