Metabolic and vascular effects of silybin in hypertensive patients with high 1-h post-load plasma glucose

Internal and Emergency Medicine
Angela SciacquaFrancesco Perticone

Abstract

Hypertensive patients with normal glucose tolerance (NGT) but 1-h post-load plasma glucose ≥ 155 mg/dl (1-h high), during an oral glucose tolerance test (OGTT), show higher insulin resistance and multiple target organ damages. Experimental and clinical studies demonstrate that silybin presents anti-inflammatory and metabolic effects, improving insulin resistance and endothelial dysfunction. This study aims to evaluate the effects of the complex silybin-vitamin E and phospholipids on inflammatory, metabolic and vascular parameters in NGT 1-h high hypertensive patients. This is a pilot, single arm, interventional, longitudinal study enrolling 50 Caucasian NGT 1-h high hypertensive outpatients, 27 men and 23 women, age range 42-60 years (mean + SD = 52 ± 7). After 6 months of silybin intake, there is a significant improvement in metabolic profile. The glucose response during OGTT significantly improves (AUCglucose0-120 309.6 ± 63.4 at baseline vs 254.6 ± 35.5 at the follow-up, ∆ = - 55, 95% CI from - 67 to - 43, p < 0.0001), so as insulin response (AUCinsulin0-120 238.2 ± 99.1 vs 159.3 ± 44.9, ∆ = - 78.9, 95% CI from - 100.0 to - 57.8, p < 0.0001), in accordance with the increase of insulin sensitivity index Matsuda. Silybin intak...Continue Reading

References

Feb 1, 1990·Diabetes Care·J P Le FlochL Perlemuter
May 28, 2003·Journal of the American College of Cardiology·Roberto CeravoloFrancesco Perticone
Aug 2, 2005·Journal of the American College of Cardiology·Francesco PerticoneCarmine Zoccali
Dec 29, 2006·Diabetes Care·Muhammad A Abdul-GhaniRalph A DeFronzo
May 26, 2007·Endocrine Reviews·Ranganath MuniyappaMichael J Quon
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jun 3, 2011·World Journal of Gastroenterology : WJG·Carmela Loguercio, Davide Festi
Jul 16, 2011·Cardiovascular Diabetology·Giovanni Li VoltiFederico Salamone
Sep 14, 2011·Diabetes Care·Angela SciacquaFrancesco Perticone
Sep 20, 2011·International Journal of Cardiology·Francesco PerticoneGiorgio Sesti
Oct 21, 2011·Diabetes Care·Francesco PerticoneGiorgio Sesti
Aug 14, 2012·Lancet·Ele Ferrannini, William C Cushman
Jun 7, 2013·Aging Clinical and Experimental Research·Davide BolignanoGiovanni Tripepi
Mar 12, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H B LiW J Jiang
Aug 15, 2015·The Journal of Clinical Endocrinology and Metabolism·Teresa Vanessa FiorentinoGiorgio Sesti

❮ Previous
Next ❯

Citations

Oct 18, 2018·Internal and Emergency Medicine·Pasquale PignatelliDanilo Menichelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.