PMID: 3288804Mar 1, 1988

Metabolic aspects of readaptation after hypokinesia (based on experimental results with animals)

Kosmicheskaia biologiia i aviakosmicheskaia meditsina
P P Potapov, I V Fedorov


This review discusses changes in protein, carbohydrate and lipid metabolism of animals during their readaptation after exposure to hypokinesia of varying duration. It is concluded that at an early stage of readaptation anabolic reactions aimed at the recovery of the bulk of active muscle proteins and the amount of energy substrates are predominant. In this situation the synthesis of lipids and carbohydrates is prevailing over their utilization. It is postulated that during readaptation amino acids are used more actively to make up for energy expenditures, gluconeogenesis and lipid synthesis. In the course of readaptation wave-like metabolic changes occur, being sometimes greater than during hypokinesia.

Related Concepts

Adaptation, Physiological
Energy Metabolism
Physical Restraint
Lipid Metabolism

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