PMID: 8945940Nov 1, 1996Paper

Metabolic basis of decreased transient outward K+ current in ventricular myocytes from diabetic rats

The American Journal of Physiology
Z XuGeorge J Rozanski

Abstract

The purpose of this study was to examine the mechanisms of alterations in cardiac K+ channel function in early stages of experimental diabetes mellitus induced by streptozotocin. Transient outward (Ito) and inward rectifier (IK1) K+ currents were recorded by the whole cell voltage-clamp technique in ventricular myocytes isolated from hearts of 2- to 4-wk diabetic and age-matched control rats. Ito density in myocytes from diabetic rats was approximately 30% less than control (at +60 mV; P < 0.01) under basal recording conditions in the presence of 18 mM external glucose, whereas IK1 density was not different between groups. When external glucose concentration was decreased to 5 mM for 4-6 h, basal Ito density was not changed in either group of myocytes. To further examine the possible metabolic basis of reduced Ito density in myocytes from diabetic rats, we separately tested three structurally different compounds that affect substrate utilization in cardiac myocytes: insulin (0.1 microM), dichloroacetate (1.5 mM), and L-carnitine (10 mM). Each compound completely normalized Ito density in myocytes from diabetic rats treated in vitro for 4-6 h. The same agents had no effect on Ito density in control myocytes, nor was IK1 altered ...Continue Reading

Citations

Oct 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shumin LiGeorge J Rozanski
Dec 12, 2018·Frontiers in Physiology·Laurel A Grisanti
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·George J Rozanski, Zhi Xu
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A NishiyamaM M Tamkun
Nov 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Xun LiGeorge J Rozanski
Apr 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Yiqiang ZhangZhiguo Wang
Sep 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Véronique A LacombeCynthia A Carnes
Jul 23, 2004·Physiological Reviews·Shari G BirnbaumLaura A Schrader
Feb 24, 2009·Canadian Journal of Physiology and Pharmacology·Mónica GallegoOscar Casis
Feb 2, 2021·World Journal of Diabetes·Nihal OzturkSemir Ozdemir

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