Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment

Oxidative Medicine and Cellular Longevity
Yan Mei GohGeorge B Hanna

Abstract

Introduction. Aerodigestive squamous cell carcinomas (ASCC) constitute a major source of global cancer deaths. Patients typically present with advanced, incurable disease, so new means of detecting early disease are a research priority. Metabolite quantitation is amenable to point-of-care analysis and can be performed in ASCC surrogates such as breath and saliva. The purpose of this systematic review is to summarise progress of ASCC metabolomic studies, with an emphasis on the critical appraisal of methodological quality and reporting. A systematic online literature search was performed to identify studies reporting metabolic biomarkers of ASCC. This review was conducted in accordance with the recommendations of the Cochrane Library and MOOSE guidelines. Thirty studies comprising 2117 patients were included in the review. All publications represented phase-I biomarker discovery studies, and none validated their findings in an independent cohort. There was heterogeneity in study design and methodological and reporting quality. Sensitivities and specificities were higher in oesophageal and head and neck squamous cell carcinomas compared to those in lung squamous cell carcinoma. The metabolic phenotypes of these cancers were simil...Continue Reading

References

Jun 3, 2004·The Journal of Nutrition·Yoshiharu ShimomuraRobert A Harris
Apr 6, 2006·International Journal of Cancer. Journal International Du Cancer·Jack CuzickThomas Iftner
Feb 12, 2009·Journal of Clinical Epidemiology·Roger M HarbordLucas M Bachmann
May 5, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Geng SongZhen-Dong Chen
Dec 31, 2010·International Journal of Cancer. Journal International Du Cancer·Jie WeiWei Jia
Oct 4, 2011·Journal of Proteome Research·Bagganahalli S SomashekarAyyalusamy Ramamoorthy
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Feb 23, 2012·American Journal of Physiology. Endocrinology and Metabolism·Kayleigh M Dodd, Andrew R Tee
Sep 11, 2012·Nature·UNKNOWN Cancer Genome Atlas Research Network
Apr 6, 2013·Molecular Cancer·Liang WangYing-Lan Zhao
Sep 1, 2007·Metabolomics : Official Journal of the Metabolomic Society·Lloyd W SumnerMark R Viant
Oct 23, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qihui WangYixiang Duan
Dec 7, 2013·Chemical Society Reviews·Hossam HaickAnton Amann
Jul 16, 2014·World Journal of Gastroenterology : WJG·Hong MaIlyar Sheyhidin
Aug 28, 2014·Journal of Proteome Research·Hai JinXianfu Gao
Sep 10, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qihui WangYixiang Duan
Dec 17, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ashish GuptaAbbas Ali Mahdi
Jan 6, 2015·Journal of Breath Research·Anna SzabóGábor Szabó
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
Feb 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Patricia Sánchez-RodríguezJesús Sánchez-Yagüe
Jun 20, 2015·BioMed Research International·Aihua ZhangXijun Wang
Oct 23, 2015·The Laryngoscope·Hagit Shoffel-HavakukDoron Halperin
Oct 30, 2015·BMJ : British Medical Journal·Patrick M BossuytUNKNOWN STARD Group
Jul 1, 2016·American Journal of Clinical Dermatology·Kyle A BurtonAmor Khachemoune
Nov 25, 2016·Briefings in Bioinformatics·Claudia ManzoniRaffaele Ferrari
Dec 22, 2016·Combinatorial Chemistry & High Throughput Screening·Jing ChengXianfu Gao
Jan 28, 2017·Journal of Animal Science and Biotechnology·Shihai ZhangShiyan Qiao

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination

Software Mentioned

MSI
QUADAS
MOOSE
Ovid
MetaboAnalyst
CAWG
R
OvidSP

Related Concepts

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.