Metabolic Biosynthesis Pathways Identified from Fecal Microbiome Associated with Prostate Cancer

European Urology
Michael A LissDimpy P Shah

Abstract

The fecal microbiome is associated with prostate cancer risk factors (obesity, inflammation) and can metabolize and produce various products that may influence cancer but have yet to be defined in prostate cancer. To investigate gut bacterial diversity, identify specific metabolic pathways associated with disease, and develop a microbiome risk profile for prostate cancer. After prospective collection of 133 rectal swab samples 2 wk before the transrectal prostate biopsy, we perform 16S rRNA amplicon sequencing on 105 samples (64 with cancer, 41 without cancer). Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) was applied to infer functional categories associated with taxonomic composition. The p values were adjusted using the false discovery rate. The α- and β-diversity analyses were performed using QIIME. The Mann-Whitney U test was employed to evaluate the statistical significance of β-diversity distances within and between groups of interest, and least absolute shrinkage and selection operator (LASSO) regression analysis was used to determine pathway significance. The detection of prostate cancer on transrectal prostate needle biopsy and 16s microbiome profile. We identified signific...Continue Reading

Citations

Aug 2, 2018·Nature Reviews. Urology·Annette Fenner
Apr 3, 2019·Cancers·Francesco MassariGiovanni Brandi
Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Holger Brüggemann, Munir A Al-Zeer
Jul 14, 2019·International Urology and Nephrology·Joseph K M LiChi-Fai Ng
Oct 23, 2019·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Feb 26, 2020·International Journal of Molecular Sciences·Makoto MatsushitaNorio Nonomura
Jul 2, 2020·Frontiers of Medicine·Solmaz Ohadian Moghadam, Seyed Ali Momeni
Jul 16, 2020·Investigative and Clinical Urology·Kwang Woo LeeYoung Ho Kim
Sep 5, 2020·Infectious Agents and Cancer·Paul KatongoleNixon Niyonzima
Sep 8, 2019·Current Urology Reports·Karen M Wheeler, Michael A Liss
Jun 18, 2020·Nature Reviews. Cancer·Johann S de BonoAndrea Alimonti
Apr 12, 2019·Frontiers in Oncology·Alessia CimadamoreMarina Scarpelli
Feb 15, 2020·Investigative and Clinical Urology·Sybil ShaVladimir Mouraviev
Oct 13, 2020·Der Urologe. Ausg. A·G MagistroC G Stief
Mar 2, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Gaeun RyuAra Koh
Oct 11, 2020·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Jun 9, 2021·Aktuelle Urologie·Michael AtzlerGiuseppe Magistro
Jul 17, 2021·Prostate Cancer and Prostatic Diseases·Juan Javier-DesLogesJ Kellogg Parsons
May 30, 2021·Cancer Science·Makoto MatsushitaNorio Nonomura
Oct 13, 2021·Annals of the New York Academy of Sciences·Jakub P PiwowarskiSebastian Granica
Dec 3, 2021·JAMA Oncology·Ming-Ming HeMingyang Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.