Metabolic bone disease in patients diagnosed with inflammatory bowel disease from Spain

Therapeutic Advances in Gastroenterology
José Miranda-BautistaLuis Menchén

Abstract

The objective of this study was to analyse the prevalence of metabolic bone disease (MBD) in a cohort of Southern European patients with inflammatory bowel disease (IBD) and to identify associated risk factors in this population. We conducted a retrospective, both cross-sectional and longitudinal study of MBD, assessed by dual energy X-ray absorptiometry (DXA), among patients diagnosed with IBD and previously recognized risk factors for this complication from two referral Spanish institutions. A total of 612 patients (58.6% diagnosed with Crohn's disease) were included. Mean (SD) age was 44.9 (14.7) years; 71.7% of patients received at least one tapered dosage of corticosteroids before first DXA. MBD and osteoporosis were diagnosed in 66.4% and 21.4% of patients, respectively. At baseline, male gender, menopause and ulcerative colitis were found as independent risks factors for osteoporosis, whereas age, more than three IBD-related hospitalizations and previous steroid treatment were found as independent risks factors for MBD. A total of 261 patients had at least a second DXA and were included in the longitudinal study; median follow up was 56.4 months. Logistic regression model identified menopause, ulcerative colitis and base...Continue Reading

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Citations

Jun 11, 2020·Nutrients·Alicja Ewa RatajczakIwona Krela-Kaźmierczak
Apr 27, 2020·Jornal de pediatria·Mahmoud Hisham Mosli, Omar Ibrahim Saadah
May 1, 2021·Journal of Clinical Medicine·Alicja Ewa RatajczakIwona Krela-Kaźmierczak
Apr 17, 2021·Current Opinion in Gastroenterology·Brindusa Truta

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SPSS
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