Metabolic cardiovascular syndrome in obese prepubertal children: the role of high fasting insulin levels

Metabolism: Clinical and Experimental
Miguel ValleRamón Cañete

Abstract

The aim of this study was to detect the presence and degree of impairment of cardiovascular disease (CVD) risk factors, grouped as metabolic cardiovascular syndrome (MCS), in obese prepubertal children. We also assessed the influence of high fasting insulin levels in this pathological status. A cross-sectional study was performed on obese children based on fasting blood samples. Subjects were 61 obese children (aged 6 to 9 years) and an equal number of non-obese children paired by age and sex. The obese children presented the following characteristics in comparison to the non-obese group: significantly high levels of insulin (8.2 +/- 0.52 v 6.12 +/- 0.34 microU/mL), triglycerides (TG) (0.79 +/- 0.04 v 0.60 +/- 0.02 mmol/L), uric acid (0.24 +/- 0.005 v 0.21 +/- 0.004 mmol/L), systolic (SBP) (94.59 +/- 1.06 v 88.85 +/- 1.2 mm Hg) and diastolic (56.49 +/- 1.07 v 52.21 +/- 1.06 mm Hg) blood pressure (DBP), and low levels of high-density lipoprotein cholesterol (HDL-C) (1.30 +/- 0.04 v 1.46 +/- 0.03 mmol/L), and nonesterified fatty acids (0.407 +/- 0.02 v 0.505 +/- 0.02 mmol/L). The hyperinsulinemic obese children showed the same types of differences when compared with the normoinsulinemic group. In the obese group, having adjusted ...Continue Reading

Citations

Sep 29, 2005·Acta Paediatrica·Maria Bitsori, Anthony Kafatos
Aug 30, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masao YoshinagaHideto Takahashi
May 29, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F GascónM A Castaño
Sep 3, 2010·Journal of Atherosclerosis and Thrombosis·Masao YoshinagaFukiko Ichida
Jan 18, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M ValleA Suanes
Nov 16, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M Gil-CamposA Gil
Jul 16, 2004·Metabolism: Clinical and Experimental·Yoo-Sun MoonDong-Keun Song

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