Metabolic changes and mitochondrial dysfunction early following transthoracic countershock in dogs.

Pacing and Clinical Electrophysiology : PACE
T G TroutonA A Adgey

Abstract

The mechanisms of myocardial injury and necrosis following transthoracic shocks from a direct current cardiac defibrillator were investigated in adult greyhounds. Myocardial lactate extraction became negative maximally at 1 minute, following two (mean -22% +/- SEM23) or five (-193% +/- 135) shocks and returned to baseline in 6-15 minutes. Myocardial necrosis assessed at 4 hours following the shock period was 0.05 g (+/- 0.03) after two shocks, 6.69 g (+/- 1.76) after five shocks and zero in controls. In further experiments, dogs received five or zero (dummy) shocks and mitochondria were isolated from their hearts following excision within 1 minute of receiving the final shock. Maximal oxygen consumption in right ventricular mitochondria was lower than the unshocked controls with both glutamate (66.9 +/- 9.4 nanoatoms of oxygen/mg per minute, n = 9 vs 86.6 +/- 13.6 nanoatoms/mg per minute, n = 7) and succinate (96.2 +/- 8.7 nanoatoms/mg per minute, n = 9 vs 119.5 +/- 14.4 nanoatoms/mg per minute, n = 7) as substrates. Using electron spin resonance spectroscopy, an increase in a peroxyl-free radical with g = 2.031 was detected in myocardial tissue after two internal shocks (50 joules stored energy, 0.5-minute intervals). We concl...Continue Reading

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E BakerB Kalyanaraman
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J L ZweierM L Weisfeldt
Oct 1, 1986·American Heart Journal·H M DunnA A Adgey
Aug 31, 1982·Biochemical and Biophysical Research Communications·K J Davies, P Hochstein
Oct 1, 1983·Journal of Molecular and Cellular Cardiology·P S RaoH S Mueller
Nov 17, 1984·British Medical Journal·C ClydeC Wilson
May 1, 1983·Annals of Internal Medicine·M MirowskiM L Weisfeldt
Jan 1, 1982·Basic Research in Cardiology·A J Drake

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Citations

Sep 29, 2011·Intensive Care Medicine·Min-Shan TsaiWen-Jone Chen
Dec 9, 2003·International Journal of Cardiology·Ijaz A Khan
Nov 15, 1996·Journal of the American College of Cardiology·M R CaterineR E Kerber
May 15, 1998·Journal of the American College of Cardiology·P B SparksJ M Kalman
Sep 4, 1998·Journal of Cardiovascular Electrophysiology·B SchumacherB Lüderitz
Sep 14, 1999·Journal of the American College of Cardiology·W TangJ Bisera
Dec 10, 1999·Journal of the American College of Cardiology·W SalibaP J Tchou
Nov 1, 2008·Critical Care Medicine·Giuseppe RistagnoMax Harry Weil
Nov 21, 2008·Critical Care Medicine·Deborah L Carlson
Oct 22, 2008·Critical Care Medicine·Min-Shan TsaiMax Harry Weil
Feb 9, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Seong-Mi ParkWan-Joo Shim
Mar 19, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Min-Shan TsaiWen-Jone Chen
Aug 13, 2005·Resuscitation·Kenneth M SteinBruce B Lerman
Jul 10, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·C BoosR S More
Sep 6, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·M G AngelosC W Callaway
Aug 9, 2001·Coronary Artery Disease·R A KlonerS Burstein
Apr 25, 2003·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·David S MarkensonUNKNOWN National Association of EMS Physicians Pediatric Task Force and Standards and Clinical Practices Committee
Jun 3, 2021·International Journal of Molecular Sciences·Nicolas ClementyDominique Babuty
Oct 31, 2007·Pediatrics·David MarkensonUNKNOWN American Academy of Pediatrics Section on Cardiology and Cardiac Surgery

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