PMID: 698161Sep 1, 1978Paper

Metabolic changes associated with the occurrence of fatty liver and kidney syndrome in chicks

The British Journal of Nutrition
C C WhiteheadM E Cleland

Abstract

1. The changes in a number of metabolic measurements brought about by low-biotin diets associated with high and low incidences of fatty liver and kidney syndrome (FLKS) were studied in healthy 4-week-old broiler chicks. 2. Liver pyruvate carboxylase (pyruvate: CO2 ligase (ADP); EC 6.4.1.1) activity was low in birds fed on a diet causing a high incidence FLKS but the addition of fat or protein to this diet, to decrease the incidence of FLKS, increased enzyme activity. 3. Liver weights, blood lactate concentrations, plasma lactate dehydrogenase (L-lactate: NAD oxidoreductase; EC 1.1.1.27) activitvities and values for C16:1 : C18:0 fatty acid in liver, adipose tissue and plasma triglyceride were highest in birds fed on the high-FLKS diet and all measurements were negatively correlated with pyruvate carboxylase activity. 4. Birds with high plasma lactate dehydrogenase activity or triglyceride C16:1 : C18:0 values were the most likely to develop FLKS when fasted. 5. There was no evidence that increased liver weight was associated with increase activities of certain other liver enzymes. 6. It is concluded that FLKS occurs in birds with little or no hepatic gluconeogenic capacity via pyruvate carboxylase as a result of a dietary insuf...Continue Reading

References

Dec 1, 1976·Australian Journal of Biological Sciences·R L HoodJ A Pearson
Sep 1, 1976·Australian Veterinary Journal·D BalnaveT M Sutherland
Aug 1, 1975·New Zealand Veterinary Journal·J E Lohr
Sep 1, 1974·British Poultry Science·C G PayneL A Hemsley
Jul 1, 1969·The Journal of Nutrition·Y Y Yeh, G A Leveille
Nov 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·E M WISE, E G BALL

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Citations

Sep 1, 1982·The British Journal of Nutrition·S SeshadriS Malhotra
May 1, 1981·The Proceedings of the Nutrition Society·C C Whitehead
Sep 1, 1981·British Poultry Science·C C Whitehead, D W Bannister
Jan 1, 1979·The International Journal of Biochemistry·D W Bannister
Jan 1, 1985·Annals of the New York Academy of Sciences·C C Whitehead
Jul 1, 1979·The Veterinary Quarterly·C C Whitehead
Oct 8, 2013·Toxicology and Industrial Health·Abdus Saboor ShahNawshad Muhammad

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