PMID: 39324Jan 1, 1978

Metabolic changes during prolonged total parenteral nutrition in intensive care

E CastelliM Zanello


Intensive care patients receiving prolonged total parenteral nutrition (TPN) developed alterations of liver function tests, seen in the activity of certain serum enzymes. Hepatomegaly and jaundice sometimes appeared. The changes in chemical pathology were in serum transaminases activity (GOT, GPT, GDH); alkaline phosphatase and gamma-glutamyltranspeptidase as indices of cholestasis; lactate dehydrogenase, hydroxybutyrate dehydrogenase and creatine phosphokinase, as enzymes related to energy metabolism; pseudocholinesterase, as a protein metabolism-related enzyme. The possible causes of these alterations in critically ill patients undergoing TPN are considered and a functional final metabolic interpretation is proposed.


Jul 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·C E BuchmillerC E Hensley
Jun 1, 1992·Zeitschrift für Ernährungswissenschaft·R F StobbaertsI De Leeuw


Feb 1, 1975·The Journal of Pediatrics·R Rager, M J Finegold
Jun 1, 1975·Journal of Pediatric Surgery·R J Touloukian, J H Seashore
Jan 1, 1968·Annual Review of Medicine·H Popper

Related Concepts

Macro-Creatine Kinase
Gamma-glutamyl transferase
Alkaline Phosphatase
Lactate Dehydrogenase
SGOT - Glutamate oxaloacetate transaminase
Liver Dysfunction

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