PMID: 6405768May 1, 1983Paper

Metabolic changes in a case of malignant hyperthermia

British Journal of Anaesthesia
H RutbergB Schildt

Abstract

A patient with fulminant MH is presented. The metabolic changes in muscle tissue, whole blood and plasma are compared with those obtained from the porcine model. The samples were taken 1 h after treatment (including dantrolene sodium) had been commenced. Increased concentrations of lactate, pyruvate and citrate were found in muscle, whereas the concentrations of potassium, free inorganic phosphate and glycogen were reduced. The ATP, ADP and phosphoryl creatine concentrations remained unchanged. In blood, increased concentrations of alanine, lactate and glycerol were observed. An increase in carbon dioxide production was found. These changes are similar to those found in the porcine model.

Citations

Jun 1, 1984·Anaesthesia·D C PhillipsM A Ness
Feb 1, 1987·Acta Neurologica Scandinavica·C LennmarkenK G Henriksson
Apr 1, 1988·Acta Neurologica Scandinavica·E BäckmanK G Henriksson
Apr 1, 1986·Acta Anaesthesiologica Scandinavica·H Rutberg, E Håkanson
Jan 1, 1989·Annales Françaises D'anesthèsie Et De Rèanimation·H Ording
Sep 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S C LeeT Sato
Feb 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·L P Rowland
Jul 1, 1992·Journal of Clinical Monitoring·H A Schwid, D O'Donnell

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