Metabolic changes in paraquat poisoned patients and support vector machine model of discrimination

Biological & Pharmaceutical Bulletin
Xianqin WangLufeng Hu

Abstract

Numerous people die of paraquat (PQ) poisoning every year in the world. Although several studies regarding paraquat (PQ) poisoning have been conducted, the metabolic changes in plasma remain unknown. In this study, the metabolomics of 15 PQ poisoned patients with plasma PQ concentrations in excess of 0.1 µg/mL and 16 healthy volunteers were investigated. The plasma samples were evaluated through the use of gas chromatography-mass spectrometry (GC/MS) and analyzed by partial least-squares discriminant analysis (PLS-DA). Based on the metabolomics data, a support vector machine (SVM) discrimination model was developed. The results showed the plasma levels of urea, glucose oxime and L-phenylalanine decreased and cholesterol increased in PQ poisoned patients in comparison to healthy volunteers. The SVM discrimination model was developed, and performed with a high degree of accuracy, to distinguish PQ poisoned patients from healthy volunteers. In conclusion, metabolic pathways including the urea cycle, and amino acid, glucose, and cholesterol metabolism were impaired after PQ poisoning. An SVM discrimination model, based on metabolomics data, was established and may become a new powerful tool for the diagnosis of PQ poisoning.

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jan 1, 1990·Human & Experimental Toxicology·P HouzéJ M Scherrmann
Jan 1, 1982·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·J LohmannH P Bertram
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ja-Ryong KooJung-Woo Noh
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Apr 4, 2006·Analytical Chemistry·Andrew CraigJohn C Lindon
Sep 13, 2008·Expert Review of Molecular Diagnostics·G A Nagana GowdaDaniel Raftery
Jun 23, 2009·The Korean Journal of Internal Medicine·Sung-Chul Yoon
May 25, 2011·Brain, Behavior, and Immunity·M Elizabeth SubletteTeodor T Postolache
May 28, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yuangao ZouLanlan Wang
Jun 10, 2011·Biomedical Chromatography : BMC·Pedro Nuno MoreiraRicardo Jorge Dinis-Oliveira

❮ Previous
Next ❯

Citations

Oct 1, 2015·Biomedical Chromatography : BMC·Congcong WenXianqin Wang
May 28, 2015·Biomedical Chromatography : BMC·Congcong WenXianqin Wang
Jul 3, 2015·Biological & Pharmaceutical Bulletin·Zhiyi WangXianqin Wang
Feb 12, 2017·Biomedical Chromatography : BMC·Yan LiGuoquan Cao
Oct 6, 2017·Toxicology and Industrial Health·Jianshe MaXianqin Wang
Aug 17, 2016·Biomedical Chromatography : BMC·Shihui BaoXianqin Wang
Apr 20, 2018·Toxicology and Industrial Health·Yahui TangZhongqiu Lu
Jul 26, 2018·Analytical and Bioanalytical Chemistry·Werickson Fortunato de Carvalho RochaDaniel W Bearden
Nov 10, 2018·BioMed Research International·Xuemei YeGuanyang Lin
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhipeng CaoDawei Guan
Nov 2, 2021·Frontiers in Microbiology·Peng JinJianrong Xia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.