PMID: 11905993Mar 22, 2002Paper

Metabolic changes in the basal ganglia of patients with Huntington's disease: an in situ hybridization study of cytochrome oxidase subunit I mRNA

Journal of Neurochemistry
Isabelle Gourfinkel-AnEtienne C Hirsch

Abstract

On the basis of the functional model of the basal ganglia developed in the 1980s and the neuropathological findings in Huntington's disease (HD), changes in the neuronal activity of the basal ganglia have previously been proposed to explain the abnormal movements observed in this pathology. In particular, it has been stated that the neurodegenerative process affecting the basal ganglia in the disease should provoke a hypoactivity in the internal segment of the pallidum (GPi) that could explain choreic movements observed in the disease. To test this functional hypothesis, we performed an in situ hybridization study on control and HD brains postmortem, taking cytochrome oxidase subunit I (COI) mRNAs expression as index of neuronal activity. As most of the HD patients studied were under chronic neuroleptic (NL) treatment, we also studied the brains of non-HD patients under chronic NL treatment. Our results show that in HD brain the number of neurons expressing COI mRNA tends to be lower in the striatum, GPe and GPi, suggesting a severe involvement of these structures during the neurodegenerative process. Moreover, COI mRNA level of expression was markedly reduced within neurons of the putamen and GPe. Surprisingly, COI mRNA expres...Continue Reading

Citations

May 14, 2010·Journal of Bioenergetics and Biomembranes·Mritunjay PandeyRajamma Usha
Feb 3, 2006·Molecular Biology of the Cell·Alexandra BenchouaEmmanuel Brouillet
Mar 24, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Sara Duarte-SilvaPatrícia Maciel

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