Metabolic changes in the patients on second-line highly active antiretroviral therapy (HAART): A prospective cohort study from north India

Journal of Family Medicine and Primary Care
Durga S MeenaDeepak Kumar

Abstract

In India, there is a genetic predisposition to insulin resistance and cardiovascular risk, the impact of ART (antiretroviral therapy) on lipid profile and blood sugar may be significant. The study of potential implications of highly active antiretroviral therapy (HAART)-associated metabolic syndrome is critical to prevent cardiovascular diseases in the Indian population. This study was done to determine the prevalence of metabolic changes (dyslipidaemia, hyperglycemia and insulin resistance) among HIV patients on second-line ART. A prospective cohort study. We enrolled 150 patients, who were started on second-line HAART. Patients were investigated for fasting blood sugar, lipid profile and insulin level at baseline and after 6 months. The data were analysed using SPSS software (version 20; IBM Corp., Armonk, N.Y., USA). Student's t-test was used to compare numerical variables in the two groups. P value < 0.05 was considered as statistically significant. There was a significant increase in serum cholesterol, LDL and triglyceride in patients with protease inhibitors (PIs) containing regimens. LDL levels were increased from 65 to 80 mg/dL (P = <.003) after treatment. Triglycerides were increased from 138 to 152 mg/dL. (P = <0.001)...Continue Reading

References

Mar 16, 2011·International Journal of General Medicine·Jyothi IdicullaSultana Furruqh
Jun 7, 2011·The Open Cardiovascular Medicine Journal·Eoin R Feeney, Patrick W G Mallon
Jun 25, 2013·Current HIV/AIDS Reports·Virginia A Triant
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Colleen Hadigan, Sarah Kattakuzhy
Feb 6, 2016·The Journal of Antimicrobial Chemotherapy·Leonardo CalzaPierluigi Viale
Aug 11, 2017·BMC Infectious Diseases·Paolo MaggiNicola Squillace
Mar 13, 2018·PloS One·Alastair D DuncanBarry S Peters
Jan 31, 2019·Journal of the International AIDS Society·Win M HanUNKNOWN IeDEA Asia-Pacific
Sep 13, 2019·Expert Opinion on Drug Metabolism & Toxicology·Maria Del Mar GutierrezPere Domingo

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.