Jun 1, 1993

Metabolic changes in the rat brain after acute and chronic ethanol intoxication: a 31P NMR spectroscopy study

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
R DenaysH R Ham

Abstract

In this work, 31P phosphorus NMR (31P NMR) studies of the brain have been conducted in rats acutely and chronically intoxicated with ethanol. In both groups, changes in levels of high-energy phosphates were observed: increase of phosphocreatinine (PCr)/beta AaTP and PCr/inorganic phosphate (Pi) in acute and long-term ethanol exposure, and decrease of Pi/beta ATP after acute ethanol administration. These changes in high-energy phosphates, indicative of a reduction of adenosine triphosphate (ATP) and PCr consumption (PCr+ ADP+ H+ ATP+ Cr; ATP ADP+ Pi), suggest a reduction of cerebral metabolism both in acute and chronic ethanol exposure. In addition, in the group of rats chronically intoxicated with ethanol, there were variations in phosphodiester peak intensities (decrease of phosphomonoester (PME)/phosphodiester (PDE), increase of PDE/beta ATP), suggesting increased breakdown of membrane phospholipids. These changes could provide a metabolic explanation for the development of cerebral atrophy in chronic alcoholism.

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  • Citations14

Citations

Mentioned in this Paper

Alcoholic Intoxication
Neoton
Ethanol
In Vivo NMR Spectroscopy
Brain
Alcoholic Intoxication, Chronic
Alcohol Abuse
Hepatitis, Alcoholic
Phospholipids
Rats, Wistar

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