Metabolic changes of anterior cingulate cortex in patients with hepatic cirrhosis: A magnetic resonance spectroscopy study

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Long Jiang ZhangJi Qi

Abstract

The anterior cingulate cortex (ACC) plays an important role in cognitive functions. The purpose of this study is to compare metabolite concentrations in the ACC of cirrhotic patients with normal controls, and to correlate metabolite changes with Child-Pugh class and with severity of hepatic encephalopathy (HE). Fifty-two cirrhotic patients and 30 healthy volunteers were included in this study. All subjects performed the number connection test type A (NCT-A) and digital symbol test (DST) before multiple resonance (MR) examinations. Single-voxel proton MR spectroscopy (MRS) data in the ACC were acquired on a 1.5-T scanner. The ratios of all metabolites to creatine and phosphocreatine (Cr) were obtained. Statistical analysis was performed to evaluate the difference between control and cirrhotic patients, with respect to metabolite ratios. The correlation between metabolite ratios and Child-Pugh scale, severity of HE, venous ammonia and neuropsychiatric test results was analyzed. The ratios of choline (Cho)/Cr and myo-inositol (mIns)/Cr were significantly lower, and the ratio of glutamine- glutamate (Glx)/Cr was significantly higher in cirrhotic patients than those in controls (P < 0.001). mIns/Cr correlated negatively with Child-P...Continue Reading

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Citations

Aug 27, 2014·American Journal of Veterinary Research·Inés CarreraMatthias Dennler
Mar 3, 2012·AJNR. American Journal of Neuroradiology·L J ZhangG M Lu
Dec 3, 2014·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Elham A HassanGhaydaa A Shehata
Mar 9, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesca CampagnaPiero Amodio
Jan 28, 2018·Metabolic Brain Disease·Xiao Dong Zhang, Long Jiang Zhang
Aug 30, 2014·World Journal of Gastroenterology : WJG·Xiao-Dong ZhangGuang-Ming Lu
Dec 18, 2014·Metabolic Brain Disease·Yun Yan SuLong Jiang Zhang

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