Metabolic changes of subcortical structures in intractable focal epilepsy

Epilepsia
Krisztina BenedekH T Chugani

Abstract

Intractable focal epilepsy is commonly associated with cortical glucose hypometabolism on interictal 2-deoxy-2[18F]-fluoro-D-glucose (FDG) positron emission tomography (PET). However, subcortical brain structures also may show hypometabolism on PET and volume changes on magnetic resonance imaging (MRI) studies, and these are less well understood in terms of their pathophysiology and clinical significance. In the present study, we analyzed alterations of glucose metabolism in subcortical nuclei and hippocampus by using FDG-PET in young patients with intractable epilepsy. Thirty-seven patients (mean age, 7.5 years; age range, 1-27 years) with intractable frontal (n = 23) and temporal (n = 14) lobe epilepsy underwent FDG-PET scanning as part of their presurgical evaluation. Normalized glucose metabolism was measured in the thalamus and caudate and lentiform nuclei, as well as in hippocampus, both ipsi- and contralateral to the epileptic focus, and correlated with duration and age at onset of epilepsy, presence or absence of secondary generalization, location of the epileptic focus, and extent of cortical glucose hypometabolism. Long duration of epilepsy was associated with lower glucose metabolism in the ipsilateral thalamus and h...Continue Reading

References

Apr 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·K Gale
Apr 27, 1992·Neuroscience Letters·S ShimosakaR P Simon
Jun 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·H MoriH Shimada
Mar 1, 1990·Epilepsia·M R SperlingM Reivich
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T R HenryD E Kuhl
Jul 1, 1987·Epilepsia·W H TheodoreM Deitz
Oct 1, 1987·Annals of Neurology·H T ChuganiJ C Mazziotta
Apr 1, 1982·Journal of Computer Assisted Tomography·M BergströmG Blomqvist
Jun 1, 1993·Archives of Neurology·T R HenryJ Engel
Oct 24, 1998·Computer Aided Surgery : Official Journal of the International Society for Computer Aided Surgery·O MuzikH T Chugani
Mar 11, 2004·Epilepsia·William H TheodoreWilliam D Gaillard

❮ Previous
Next ❯

Citations

Jun 27, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sandeep Sood, Harry T Chugani
Nov 9, 2007·Neuropsychology Review·Michael SeidenbergBruce Hermann
Feb 14, 2007·Epilepsia·Regula S BriellmannGraeme D Jackson
Oct 23, 2009·Epilepsia·Bruno A G CamposFernando Cendes
Jun 14, 2012·Epilepsia·Firas FahoumJean Gotman
Jun 4, 2010·Expert Review of Neurotherapeutics·Mark Richardson
Oct 8, 2013·Seminars in Nuclear Medicine·Ilya Nasrallah, Jacob Dubroff
Dec 29, 2015·Seizure : the Journal of the British Epilepsy Association·Haitao ZhuGang Zheng
Apr 1, 2010·PET Clinics·Abass Alavi, Andrew B Newberg
May 8, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Bálint AlkonyiCsaba Juhász
Feb 27, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark Richardson
Jul 20, 2007·Developmental Medicine and Child Neurology·Carlos E A BatistaH T Chugani
Jan 27, 2006·Annals of Neurology·Carlo Di BonaventuraAnna T Giallonardo
May 12, 2012·Acta Neurologica Scandinavica·J W PanS S Spencer
Jul 31, 2013·Epilepsia·Jullie W PanDennis D Spencer
Jan 14, 2012·Annals of the New York Academy of Sciences·Abass AlaviAndrew B Newberg
Feb 7, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Shigetoshi TakayaHidenao Fukuyama
Feb 20, 2014·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Ranno ViitmaaLiisa Metsähonkala
Feb 8, 2005·Radiologic Clinics of North America·Andrew B Newberg, Abass Alavi
Sep 22, 2015·Frontiers in Neurology·Elisa EvangelistaFabrice Bartolomei
Jan 25, 2011·Epilepsy & Behavior : E&B·Thomas R Henry, Deborah D Roman
Sep 6, 2018·Journal of Child Neurology·Ananyaa KumarHarry T Chugani
Jan 8, 2018·Neurosurgical Review·Tim A M Bouwens van der VlisLinda Ackermans
Jan 25, 2008·Journal of Neurophysiology·Olivier Darbin, Thomas Wichmann
Dec 21, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Lorenzo MuccioliFrancesca Bisulli
Oct 30, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Zeenat JaisaniArie L Weinstock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.