Metabolic characterization of asthenozoospermia using nontargeted seminal plasma metabolomics

Clinica Chimica Acta; International Journal of Clinical Chemistry
Xiaoli ZhangZhiming Cai

Abstract

Asthenozoospermia (AS) is a common cause of male infertility. Due to the limitation of routine semen analysis, metabolic alterations associated with the disease are unclear. We applied a metabolic profiling strategy as a surrogate method to accurately assess and provide new insights into the etiologies of asthenozoospermia. Seminal plasma samples from patients diagnosis with asthenozoospermia (n=33) and healthy subjects (n=30) were investigated using a nontargeted metabolomics approach based on proton nuclear magnetic resonance ((1)H NMR) spectroscopy. The spectral data were then subjected to multivariate and univariate analyses to identify metabolites that were correlated with asthenozoospermia. The disturbed metabolic pathways which the biomarkers were involved in were analyzed. Nineteen metabolites including up-regulation or down-regulation of several amino acids, changes in lipids metabolism, phospholipids (choline) metabolism, cholesterol metabolism, nucleoside metabolism, the Krebs cycle and energy metabolism were identified and associated with asthenozoospermia. In particular, the elevation of oxysterols such as 5α-cholesterol and 7-ketocholesterol in seminal plasma of patients with asthenozoospermia was an important fin...Continue Reading

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Citations

Sep 1, 2016·Journal of Proteomics·Meritxell JodarUNKNOWN Molecular Biology of Reproduction and Development Research Group
Jan 27, 2017·International Journal of Molecular Sciences·Zhe ZhangHui Jiang
Sep 18, 2018·Human Fertility : Journal of the British Fertility Society·Rana Ghandehari-AlavijehMohammad Hossein Nasr-Esfahani
Apr 11, 2018·PloS One·Ana Luiza Cazaux VelhoErdogan Memili
Feb 15, 2020·Metabolites·Federica MurgiaGiovanni Monni
Jul 1, 2020·Andrologia·Manesh Kumar Panner SelvamRalf Henkel
Jul 28, 2020·Journal of Assisted Reproduction and Genetics·Filipe Tenorio Lira NetoRicardo Oliveira Silva
Aug 10, 2020·Andrology·Magalie BoguenetPascale May-Panloup
Jul 15, 2017·Archives of Gynecology and Obstetrics·Isarin ThanaboonyawatRoungsin Choavaratana
Nov 1, 2020·Journal of Magnetic Resonance Imaging : JMRI·Athina C TsiliMaria I Argyropoulou
Nov 4, 2020·Open Biology·Gitanjali AsampilleHanudatta S Atreya
Apr 11, 2020·Animal Reproduction Science·Erdogan MemiliAbdullah Kaya
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Marta LombóMaría-Jesús Sánchez-Calabuig
Jul 30, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H AlipourG Van Der Horst

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