Metabolic clearance rate of radioiodinated human calcitonin in man

The Journal of Clinical Investigation
R ArdaillouC Beaugas

Abstract

The characteristics of the disappearance of radioiodinated synthetic human calcitonin from plasma have been studied in man. After single injection the disappearance curve was multiexponential. The number of exponentials of the theoretical curve fitting the best with the experimental data varied individually. Metabolic clearance rate was determined both from single injection and constant infusion studies, and fast initial distribution volume from the former. Metabolic clearance rate values in normal man calculated from constant infusion studies were 82.3 +/-3.4 ml/min per m(2). Values derived from single injection studies were similar, 77.0 +/-4.7 ml/min per m(2). These results were compared to those obtained in end stage, renal failure patients. Metabolic clearance rate was considerably lower and volume of fast initial distribution slightly larger in that group. This fact emphasizes the important role of kidneys in the utilization and/or the degradation of human calcitonin.

References

Jul 12, 1969·Lancet·M B ClarkG V Foster
Jan 1, 1969·The Journal of Endocrinology·J LeggateS C Frazer
Dec 1, 1969·The Journal of Clinical Investigation·A L TaylorD H Mintz
Dec 1, 1969·The Journal of Endocrinology·T E WestA D Care
Sep 1, 1968·The Journal of Clinical Investigation·M P SternG M Reaven
Oct 1, 1968·The Journal of Clinical Endocrinology and Metabolism·S L KaplanM M Grumbach
Oct 31, 1968·Helvetica Chimica Acta·B RinikerI MacIntyre
Aug 1, 1969·The Journal of Clinical Investigation·A SilversG M Reaven
Sep 1, 1969·The Journal of Clinical Investigation·D P CameronA Doig
Jun 1, 1967·The Journal of Clinical Investigation·W D OdellP G Condliffe
Dec 1, 1963·The Journal of Clinical Endocrinology and Metabolism·J F TAIT

❮ Previous
Next ❯

Citations

Dec 1, 1978·The American Journal of Digestive Diseases·C OwyangV L Go
Mar 1, 1988·Calcified Tissue International·T Onishi, L J Deftos
Aug 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Rojanasathit, J G Haddad
Jan 11, 2000·Domestic Animal Endocrinology·H A HazewinkelJ A Mol
Apr 1, 1971·The New England Journal of Medicine·O L BijvoetA T van Koppen
Jun 1, 1974·European Journal of Clinical Investigation·G Heynen, P Franchimont
Mar 16, 1981·Klinische Wochenschrift·Z S Szabó, F Ritzl
Feb 1, 1979·Clinical Endocrinology·J A KanisG Heynen
Jan 1, 1982·Clinical Endocrinology·T CundyC G Woods
Dec 1, 1982·European Journal of Clinical Investigation·M BenmansourR Ardaillou
Jan 1, 1976·The Journal of Pediatrics·A W Root, H E Harrison
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E F NemethJ Fox
Jan 1, 1980·Acta Medica Scandinavica·H E NielsenO Brandsborg
Jun 1, 1990·Journal of Endocrinological Investigation·M PedrazzoniM Passeri
Jan 1, 1979·Acta Medica Scandinavica·H E NielsenK J Olsen
Jan 1, 1985·Uremia Investigation·C BianchiP Salvadori
Jan 22, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M BrauckhoffH Dralle
Jan 1, 1979·The American Journal of Physiology·R HuwylerJ A Fischer
Sep 29, 1973·Lancet·E B KnightsG V Foster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.