Metabolic comorbidities and male sex influence steatosis in chronic hepatitis C after viral eradication by direct-acting antiviral therapy (DAAs): Evaluation by the controlled attenuation parameter (CAP).

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Annalisa CespiatiAnna Ludovica Fracanzani

Abstract

Chronic hepatitis C (CHC) is associated with hepatic steatosis, related to both a direct viral action and metabolic features. Vice-versa data on hepatic steatosis after viral eradication by direct-acting antiviral agents (DAA) are undefined although the presence of metabolic alterations could strongly influence the occurrence of steatosis as in NAFLD. The controlled attenuation parameter (CAP) (FibroscanⓇ) allows the qualitative and quantitative evaluation of fatty liver. to evaluate in patients with CHC whether hepatic steatosis diagnosed by CAP modifies after DAAs-induced sustained virologic response (SVR). Data were collected the day of DAAs therapy starting and six months after SVR. CAP ≥ 248 dB/m defined the presence of steatosis. 794 CHC SVR patients referring to 2 Italian Units were enrolled. Mean age was 64 ± 16 ys, 50% males, BMI 25.4 ± 4 kg/m2, genotype type-1 in 73%, type-3 in 8%. Prevalence of hepatic steatosis at baseline was 32% by US and 46% by CAP. De novo steatosis developed in 125 (29%), resolution in 122 (30%). At multivariate analysis de novo steatosis was independently associated with male sex (OR 1.7, CI 95% 1.09-2.67; p = 0.02) and baseline BMI (for unit increase OR 1.19, CI 95%1.11-1.29; p < 0.001). Base...Continue Reading

References

Jul 25, 2000·Journal of Hepatology·L Rubbia-BrandtF Negro
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L E AdinolfiG Ruggiero
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriel PerlemuterChristian Bréchot
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shruti H MehtaDavid L Thomas
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thierry PoynardJanice Albrecht
Sep 23, 2003·The American Journal of Gastroenterology·Arun J SanyalA Scott Mills
Oct 28, 2004·Gastroenterology·Giovanna FattovichFrancesco Donato
Jan 27, 2006·Journal of Viral Hepatitis·A LonardoG Ruggiero
Nov 30, 2006·World Journal of Gastroenterology : WJG·Manuel Romero-Gómez
Feb 16, 2008·Internal and Emergency Medicine·Amedeo LonardoNicola Carulli
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Alfredo Alberti
Oct 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G MussoM Cassader
Oct 23, 2009·Journal of Hepatology·Srinivasan DasarathyArthur J McCullough
Nov 3, 2010·Journal of Gastroenterology and Hepatology·Vincent Wai-Sun Wong, Henry Lik-Yuen Chan
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben HernaezJeanne M Clark
Apr 12, 2014·The New England Journal of Medicine·Jordan J FeldBarry Bernstein
Jun 27, 2014·World Journal of Gastroenterology : WJG·Amedeo LonardoPaola Loria
Sep 10, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eric G MeissnerShyam Kottilil
Apr 12, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
Nov 4, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Jacqueline A BachofnerJoachim C Mertens
Nov 7, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cyrielle CaussyRohit Loomba
Apr 16, 2018·Gastroenterology·Vincenza CalvarusoUNKNOWN Rete Sicilia Selezione Terapia–HCV (RESIST-HCV)
Mar 30, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amedeo LonardoAyako Suzuki
Aug 27, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Hanan SolimanSherief Abd-Elsalam
Oct 28, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Steve M NelsonJayanta Chaudhuri
Nov 7, 2019·World Journal of Gastroenterology : WJG·Giovanna Ferraioli, Livia Beatriz Soares Monteiro
Nov 23, 2019·Current Pharmaceutical Design·Rosa LombardiAnna L Fracanzani

❮ Previous
Next ❯

Citations

Aug 8, 2021·International Journal of Molecular Sciences·Vaia ValiakouPelagia Foka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.