Metabolic compensation and depression in Alzheimer's disease

Dementia and Geriatric Cognitive Disorders
A CaroliG B Frisoni

Abstract

The aim of this study was to map metabolic compensation and depression in Alzheimer's disease (AD) on a voxel-by-voxel basis. Twenty-one healthy elderly subjects and 25 AD patients underwent cerebral MR and FDG-PET imaging. All images were processed with SPM2, and whole-brain gray matter (GM) atrophy and hypometabolism maps were computed. Metabolic compensation and depression were assessed using Biological Parametric Mapping software. GM atrophy and hypometabolism mapped to similar regions, with varying degrees of severity. Significant metabolic compensation was found in the amygdala, while exceeding hypometabolism was mainly located in the posterior cingulate cortex. Metabolic depression can be due to both distant effects of atrophy and to additional hypometabolism-inducing factors, such as amyloid deposition. Conversely, metabolic compensation could reflect spared synaptic plasticity of the surviving neurons. The investigation of the metabolic compensation mechanism could help in the comprehension of the AD underlying pathology.

Citations

Mar 2, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Silvia MorbelliFlavio Nobili
Oct 21, 2015·Journal of Alzheimer's Disease : JAD·David BensamounRenaud David
Sep 1, 2015·Neuropsychology Review·Shailendra SegobinFrancis Eustache
Jan 30, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Matthias BrendelUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 5, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Annapaola PrestiaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 19, 2018·Cerebral Cortex·Alexandre BejaninGaël Chételat
Feb 26, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias BrendelAxel Rominger

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