Metabolic complications of obesity in childhood and adolescence: more than just diabetes

Current Opinion in Endocrinology, Diabetes, and Obesity
Brandon M Nathan, Antoinette Moran

Abstract

The alarming increase in the prevalence of pediatric obesity has led to a rise in associated metabolic complications in worldwide pediatric populations. This review summarizes recent literature on detection, pathophysiology, and potential intervention strategies for the metabolic derangements encountered in the overweight pediatric population. Development of metabolic complications associated with obesity during childhood track into adulthood and increase the risk for type 2 diabetes and early cardiovascular disease. Clustering of these metabolic abnormalities, which include insulin resistance, hypertension and dyslipidemia, constitutes the metabolic syndrome, which may affect up to 50% of overweight adolescents. Other serious disorders associated with obesity and insulin resistance include polycystic ovary disease and fatty liver. Family and school-based programs focusing on lifestyle modifications, as well as pharmacotherapy, have shown preliminary promise in reversing some of these derangements. As the trend in pediatric obesity continues to rise, providers must effectively identify children at risk for metabolic disturbances and implement long-lasting, successful treatment regimens. Continued research into the predecessors ...Continue Reading

References

Nov 1, 1995·The Journal of Pediatrics·A D BaldridgeJ E Lavine
Sep 26, 1997·The New England Journal of Medicine·R C WhitakerW H Dietz
Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Feb 24, 2001·Nature·C M SteppanM A Lazar
Apr 11, 2001·The Journal of Pediatrics·J SteinbergerA R Sinaiko
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·L IbáñezF de Zegher
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Mar 5, 2002·Journal of Hypertension·Alan R SinaikoDavid R Jacobs
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Mark R PalmertAndrea Dunaif
Mar 15, 2002·The New England Journal of Medicine·Ranjana SinhaSonia Caprio
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Oct 2, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K H SchmitzA R Sinaiko
Mar 4, 2003·Pediatrics·Matthew W GillmanGraham A Colditz
Sep 16, 2003·Obesity Research·Julia SteinbergerAlan R Sinaiko
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Miriam E SilfenSharon E Oberfield
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Jun 4, 2004·The New England Journal of Medicine·Ram WeissSonia Caprio
Dec 18, 2004·Science·Atsunori FukuharaIichiro Shimomura
Mar 25, 2005·The New England Journal of Medicine·David A Ehrmann
Mar 29, 2005·Diabetes Care·Ram WeissSonia Caprio

❮ Previous
Next ❯

Citations

Oct 8, 2009·Reviews in Endocrine & Metabolic Disorders·Katie Larson OdeBrandon M Nathan
Jun 14, 2013·Eating and Weight Disorders : EWD·Renata BracaleMichele O Carruba
Jul 4, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C BrienzaE Miraglia del Giudice
Nov 8, 2011·Journal of Community Health Nursing·Jill Gaffney Valde
Dec 15, 2011·Journal of Child and Adolescent Psychopharmacology·Lawrence Maayan, Christoph U Correll
Jul 13, 2011·Journal of Pediatric Psychology·William MartinezLauren Jennifer Legato
May 18, 2012·BMC Public Health·Hazzaa M Al-HazzaaAbdulrahman O Musaiger
May 6, 2010·BMC Endocrine Disorders·Anna GrandoneEmanuele Miraglia Del Giudice
Jan 4, 2013·PloS One·Teatske M AltenburgMai J M Chinapaw
Aug 10, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gili Yaeger-YaromAlon Eliakim
Jul 14, 2010·International Journal of Environmental Research and Public Health·Sigrídur P EiõsdóttirJohn P Allegrante
Aug 19, 2010·International Journal of Environmental Research and Public Health·Fatma G HuffmanManthan Patel
Apr 5, 2014·Actas dermo-sifiliográficas·E Baselga Torres, M Torres-Pradilla
Sep 24, 2010·International Journal of Pediatrics·Marie-Eve MathieuAngelo Tremblay
Jul 10, 2013·European Journal of Pediatrics·Francesco MartinoFrancesco Barillà
Oct 23, 2013·Journal of Nutrition Education and Behavior·Kelly R Rice, Stewart G Trost
May 9, 2012·Clinical Biochemistry·Valeria HirschlerUNKNOWN San Antonio de los Cobres Study Group
Feb 14, 2012·Journal of Pediatric Nursing·Eric A HodgesDiane Berry
Nov 19, 2011·Pediatric Clinics of North America·Grace Kim, Sonia Caprio
Jan 18, 2011·American Journal of Preventive Medicine·Dianna D InmanDavid R Garr
Apr 30, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Teresa Flores-DorantesSamuel Canizales-Quinteros
Jan 26, 2010·Diabetes Research and Clinical Practice·Claudio L LafortunaAlessandro Sartorio
Apr 25, 2009·Obesity·Arlette SantacruzUNKNOWN EVASYON Study Group
Oct 23, 2015·Journal of Pediatric Surgery·Françoise SchmittNatacha Bouhours-Nouet
Jun 28, 2011·Journal for Specialists in Pediatric Nursing : JSPN·Judith O'HaverBernadette Mazurek Melnyk
May 1, 2016·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Aline Dill WinckLetiane Bueno Zanatta
Jan 28, 2014·Ultrasound in Medicine & Biology·Bülent HacıhamdioğluEmine Çamtosun
Sep 13, 2015·Clinical Therapeutics·Jennifer G KendrickMary H H Ensom
Mar 19, 2014·Physiology & Behavior·Silvana JacobsGilberto L Sanvitto
Dec 2, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lucia PacificoClaudio Chiesa
Mar 18, 2015·Journal of Child and Adolescent Psychopharmacology·Zohar LandauGal Shoval
Jan 24, 2014·Childhood Obesity·David L Katz
Oct 30, 2014·Childhood Obesity·Kiyah J DuffeySara E Benjamin Neelon
Sep 6, 2013·Childhood Obesity·Kelly R RiceStewart G Trost
Jul 13, 2016·Current Problems in Pediatric and Adolescent Health Care·Karin Russ, Sarah Howard
Mar 23, 2010·Cell·Carl Nathan, Aihao Ding
Feb 2, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Lubia Velázquez LópezJorge Escobedo de la Peña

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Current Opinion in Pediatrics
Jeffrey M Saland
Best Practice & Research. Clinical Endocrinology & Metabolism
John J Reilly
Pediatrics
National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
© 2021 Meta ULC. All rights reserved