PMID: 7324500Oct 1, 1981Paper

Metabolic conjugation of some carboxylic acids in the horse

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M V MarshM S Moss

Abstract

1. 14C-Labelled benzoic acid, salicylic acid and 2-naphthylacetic acid were administered orally to horses, and urinary metabolites investigated by chromatographic and mass spectral techniques. 2. [14C]Benzoic acid (5 mg/kg) was eliminated rapidly in the urine, and quantitatively recovered in 24 h. The major urinary metabolite was hippuric acid (95% of dose) with much smaller amounts of benzoic acid, benzoyl glucuronide and 3-hydroxy-3-phenylpropionic acid. Administration of [ring-D5]benzoic acid together with [14C]benzoic acid to a pony permitted the mass spectral determination of metabolites of the exogenous benzoic acid metabolites in the presence of the same endogenous compounds. 3. [14C]Salicylic acid (35 mg/kg) was eliminated rapidly in the urine, 98% of the 14C dose being excreted in 24 h. The major excretion product was unchanged salicylate (94% of dose). Gentisic acid, salicyluric acid and the ester and ether glucuronides of salicylic acid were very minor metabolites. 4. 2-Naphthyl[14C]acetic acid (2 mg/kg) was excreted very slowly in the urine, with 53 and 77% of the 14C dose being recovered in six days. 2-Naphthylacetylglycine was the major metabolite (26 and 38% dose) and in addition, the glucuronic acid and taurine ...Continue Reading

References

Sep 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T S EmudianugheR L Smith
Apr 1, 1959·The Biochemical Journal·B C BALDWINR T Williams
Mar 30, 1960·Annals of the New York Academy of Sciences·P K SMITH

Citations

Jan 1, 1992·European Journal of Drug Metabolism and Pharmacokinetics·J S SalonenG A Maylin
Jun 1, 1983·Biochemical Pharmacology·J Caldwell, M V Marsh
Jul 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·F T DelbekeM Debackere
Mar 28, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·F T DelbekeP De Backer
Mar 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·C R ShortL E Davis
Oct 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·F T DelbekeM Debackere
Apr 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·R SamsS M Ashcraft
Apr 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M V MarshM S Moss
Oct 23, 2010·Drug Testing and Analysis·James P ScarthTiia Kuuranne
Jul 1, 1986·Journal of Clinical Pharmacology·T A Baillie, A W Rettenmeier
Apr 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P B SmithM S Moss
Oct 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A J HuttR L Smith

Related Concepts

2-naphthylacetic acid, sodium salt
Benzoate
Carboxylic Acids
Naphthaleneacetic Acids
Salicylic Acids
Ucephan
Salicylic Acid

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