Metabolic Considerations in Atrial Fibrillation - Mechanistic Insights and Therapeutic Opportunities

Circulation Journal : Official Journal of the Japanese Circulation Society
Masahide HaradaS Nattel

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and is associated with morbidity and mortality. Over the past 2 decades, there have been major advances in understanding AF pathophysiology, but important knowledge gaps, particularly about targetable basic mechanisms, remain. Recent metabolomic and proteomic studies have shown changes in the expression of molecules involved in metabolic pathways in human and experimental AF, indicating a role for metabolic alterations in AF pathophysiology. AF is characterized by irregular high-frequency excitation and contraction that affect atrial energy demands, circulation and oxygen supply, and change the balance between metabolic demand and supply, causing metabolic stress. Here, we review the information available about AF-induced metabolic changes and their pathophysiological contribution. We also discuss the possibilities of developing novel therapeutic strategies that act by modulating cardiac metabolic processes during AF.

References

May 16, 2000·Journal of Cardiovascular Electrophysiology·O BarbeyJ M Maixent
Nov 18, 2000·The Journal of Biological Chemistry·S FrantzT Bourcier
Dec 12, 2001·Journal of Molecular and Cellular Cardiology·J AusmaM Borgers
Mar 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Yong-Mei ChaMargaret M Redfield
Dec 5, 2003·Journal of Molecular and Cellular Cardiology·Bartosz BalanaUrsula Ravens
Mar 29, 2005·Molecular and Cellular Biochemistry·Evelin SeppetEnn K Seppet
Oct 26, 2005·Journal of Molecular and Cellular Cardiology·Guillaume LamiraultMarja Steenman
May 29, 2007·Journal of Clinical Pathology·Hyung-Wook ParkHye-Ran Kim
Feb 2, 2008·Journal of the American College of Cardiology·Manuel MayrA John Camm
May 24, 2008·Journal of the American College of Cardiology·Emmanuel I SkalidisPanos E Vardas
Jun 17, 2008·Molecular and Cellular Biochemistry·Jérôme KalifaMonique Bernard
Sep 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tomohiro IchikawaMasakazu Ichinose
Oct 8, 2009·Circulation. Arrhythmia and Electrophysiology·Andreas S Barth, Gordon F Tomaselli
Oct 16, 2009·The Journal of Biological Chemistry·Yasumasa IkedaKenneth Walsh
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
May 28, 2010·Journal of Cardiovascular Pharmacology·Gary D Lopaschuk, Jagdip S Jaswal
Jul 27, 2010·Journal of Molecular and Cellular Cardiology·Ayesha I De SouzaStanley Nattel
May 10, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jun GuYuanlong Wang
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jiahui YuBaofeng Yang
Sep 21, 2011·International Journal of Cardiology·Tze-Fan ChaoShih-Ann Chen
Dec 27, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Carlos SánchezBlanca Rodríguez
Jun 23, 2012·Frontiers in Physiology·Kai FriedrichsAnna Klinke
Jun 29, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Li ShengYue Li
Aug 17, 2012·Circulation. Arrhythmia and Electrophysiology·Masahide HaradaStanley Nattel
Sep 14, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Naohiko TakahashiTetsunori Saikawa

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Citations

Mar 3, 2018·Circulation Research·Jordi HeijmanStanley Nattel
Mar 19, 2019·Circulation. Arrhythmia and Electrophysiology·Beatrix ScholzFrank Ulrich Müller
Sep 22, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Henry SutantoJordi Heijman
Jun 23, 2019·Metabolomics : Official Journal of the Metabolomic Society·Juntuo ZhouMing Cui
Jun 7, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Petra BüttnerJelena Kornej
Jul 1, 2020·Frontiers in Physiology·Luca SoattinThomas Jespersen
Oct 13, 2020·Frontiers in Physiology·Hamish M Aitken-BuckRegis R Lamberts
Dec 2, 2020·Basic Research in Cardiology·Fleur E MasonNiels Voigt
Mar 2, 2021·Diabetes Research and Clinical Practice·Dimitrios A VrachatisGeorgios Giannopoulos
Jun 3, 2021·Journal of Clinical Medicine·Paweł Muszyński, Tomasz A Bonda
Aug 28, 2021·International Journal of Molecular Sciences·Lisa PoolBianca J J M Brundel
Sep 12, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Francis J A LeblancStanley Nattel

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