Metabolic constraints on synaptic learning and memory

Journal of Neurophysiology
Jan Karbowski

Abstract

Dendritic spines, the carriers of long-term memory, occupy a small fraction of cortical space, and yet they are the major consumers of brain metabolic energy. What fraction of this energy goes for synaptic plasticity, correlated with learning and memory? It is estimated here based on neurophysiological and proteomic data for rat brain that, depending on the level of protein phosphorylation, the energy cost of synaptic plasticity constitutes a small fraction of the energy used for fast excitatory synaptic transmission, typically 4.0-11.2%. Next, this study analyzes a metabolic cost of new learning and its memory trace in relation to the cost of prior memories, using a class of cascade models of synaptic plasticity. It is argued that these models must contain bidirectional cyclic motifs, related to protein phosphorylation, to be compatible with basic thermodynamic principles. For most investigated parameters longer memories generally require proportionally more energy to store. The exceptions are the parameters controlling the speed of molecular transitions (e.g., ATP-driven phosphorylation rate), for which memory lifetime per invested energy can increase progressively for longer memories. Furthermore, in general, a memory trace ...Continue Reading

References

Apr 1, 1996·Trends in Neurosciences·W C Abraham, M F Bear
Apr 1, 1996·Neural Computation·W B Levy, R A Baxter
Jan 31, 1998·Science·P De Koninck, H Schulman
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·C C PetersenJ J Hopfield
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·R G Shulman, D L Rothman
Jan 15, 1999·Science·U S Bhalla, R Iyengar
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·R G ShulmanF Hyder
Apr 9, 1999·Nature Neuroscience·S B LaughlinJ C Anderson
Jul 17, 1999·Nature·K VisscherS M Block
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Attwell, S B Laughlin
Feb 8, 2002·Neuron·Bernardo L SabatiniKarel Svoboda
Feb 19, 2002·Nature Neuroscience·Erin N StarVenkatesh N Murthy
Jun 7, 2002·Nature·Aren J Borgdorff, Daniel Choquet
Jul 10, 2003·Trends in Neurosciences·Haruo KasaiHiroyuki Nakahara
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Esther A NimchinskyKarel Svoboda
Mar 5, 2004·Journal of Neurophysiology·Maxim VolgushevUlf T Eysel
Jul 24, 2004·Trends in Neurosciences·Robert G ShulmanFahmeed Hyder
Nov 16, 2004·Trends in Neurosciences·Johanna M Montgomery, Daniel V Madison
Dec 2, 2004·The Journal of Biological Chemistry·Mark O CollinsSeth G N Grant
Feb 22, 2005·Neuron·Stefano FusiL F Abbott
Jun 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel H O'ConnorSamuel S-H Wang
Jul 5, 2005·Nature Neuroscience·Grant R J GordonJaideep S Bains
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiaobing ChenThomas S Reese
Aug 20, 2005·PLoS Computational Biology·Arnold Hayer, Upinder S Bhalla
Oct 18, 2005·Neurobiology of Aging·Paul E Gold
Feb 3, 2006·Molecular & Cellular Proteomics : MCP·Jonathan C TrinidadAlma L Burlingame
Jun 17, 2006·Annual Review of Neuroscience·Marcus E Raichle, Mark A Mintun
Oct 25, 2006·Annual Review of Physical Chemistry·Hong Qian
Jan 25, 2007·Annual Review of Biochemistry·Morgan Sheng, Casper C Hoogenraad
Feb 21, 2007·Nature Neuroscience·Pascal JourdainAndrea Volterra
May 11, 2007·Cerebral Cortex·Christian Leibold, Richard Kempter
Dec 7, 2007·PLoS Computational Biology·Michael Graupner, Nicolas Brunel
Apr 22, 2008·Nature Reviews. Neuroscience·Lorenzo A Cingolani, Yukiko Goda
May 23, 2008·Neuroscience·Y PankratovA Verkhratsky
Jun 13, 2008·Nature·Nikos K Logothetis
Jan 17, 2009·PLoS Computational Biology·Adam B BarrettMark C W van Rossum
Apr 8, 2009·Biophysical Journal·Andrea GrafmüllerReinhard Lipowsky

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Citations

Feb 11, 2020·Frontiers in Physiology·Warren W Burggren
Feb 3, 2021·Journal of Computational Neuroscience·Jan Karbowski
Apr 3, 2021·Communicative & Integrative Biology·Tobore Onojighofia Tobore

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