Metabolic control and growth during exclusive growth hormone treatment in X-linked hypophosphatemic rickets

Hormone Research
Outi MäkitieIlkka Sipila

Abstract

GH may improve phosphate balance and height in X-linked hypophosphatemic rickets (XLH). This study evaluated the impact of exclusive rhGH therapy on phosphate homeostasis and growth. Ten children (median age 12.2 years) with XLH were included in a 12-month trial with GH. Conventional treatment was discontinued 1 month prior GH (0.033 mg/kg/day); 1alpha-hydroxyvitamin D was added at 6 months and oral phosphate at 12 months, when GH was discontinued. Patients were followed 1-3 monthly until 18 months for clinical, biochemical and radiographic parameters. Serum phosphate Z-score increased significantly from baseline at 6 months (p = 0.005) and 9 months (p = 0.009) but returned to baseline by 12 months. Serum 1,25-dihydroxyvitamin D also increased significantly. Parathyroid function normalized. The median height Z-score was -2.2 (-2.7 to +0.4) at GH onset and -1.7 (-2.3 to +0.3) at 12 months. One patient showed a significant increase in radiographic rickets activity and 3 patients aggravation of lower limb deformity; the others showed no changes or improvement in these parameters. GH treatment improved serum phosphate and 1,25-dihydroxyvitamin D, normalized parathyroid function and improved longitudinal growth in XLH. It may howeve...Continue Reading

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Citations

Dec 8, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·James GardnerKenneth McCormick
May 27, 2010·Srpski arhiv za celokupno lekarstvo·Brankica Spasojević-DimitrijevaDusan Paripović
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Feb 21, 2019·International Journal of Oral Science·En LuoQianming Chen
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Apr 6, 2021·Frontiers in Endocrinology·Michaël R LaurentJohan Vande Walle
Aug 24, 2021·Frontiers in Endocrinology·Giampiero Igli Baroncelli, Stefano Mora

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