Metabolic control and hypoglycaemia in people with type 2 diabetes on conventional or intensified insulin therapy: a 22 year retrospective single centre survey

Diabetes/metabolism Research and Reviews
G KramerU A Müller

Abstract

Multiple insulin injection therapy can easily be adapted to the patient's needs. Therefore, it is supposed that more intensive insulin therapy is associated with better metabolic control and less hypoglycaemia compared with a conventional insulin strategy in patients with type 2 diabetes. HbA1c and incidence of non-severe and severe hypoglycaemia were analysed with regard to the strategy of insulin therapy [multiple insulin injection therapy with preprandial insulin with or without basal insulin or conventional insulin therapy with twice-daily premix insulin] from 20 943 visits of 1417 people treated with insulin with type 2 diabetes in a university outpatient department for endocrinology and metabolic diseases over a period of 22 years. Multiple insulin injection therapy was used in 13 896 (66.4%) of all 20 942 visits. Compared with conventional insulin therapy, these patients were younger (62.0 vs 68.7 years; p < 0.001), had a slightly longer diabetes duration (16.5 vs 15.8 years; p < 0.001) and higher body mass index (32.8 vs 30.9 kg/m(2) ; p < 0.001), a higher insulin dose (76.4 vs 46.5 IU/day; p < 0.001), more frequent blood glucose monitorings/week (24.2 vs 14.8; p < 0.001), a slightly lower HbA1c [7.7 (61.2) vs 7.9% (62....Continue Reading

References

Sep 25, 2007·The New England Journal of Medicine·Rury R HolmanUNKNOWN 4-T Study Group
Nov 20, 2012·Family Practice·Alexander SämannUlrich A Müller
Nov 12, 2013·The Cochrane Database of Systematic Reviews·Bianca HemmingsenJørn Wetterslev
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jan 17, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·C WangI Idris

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Citations

Nov 21, 2018·Diabetes, Obesity & Metabolism·Ulrik Pedersen-BjergaardKamlesh Khunti

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