PMID: 7939368Jul 1, 1994Paper

Metabolic control in insulin-dependent diabetes mellitus, as reflected in the in vitro effects of platelets on endothelial cell proliferation and prostacyclin production

Scandinavian Journal of Clinical and Laboratory Investigation
P FalkeI Mattiasson


We tested the hypothesis that the degree of metabolic control in diabetes mellitus may be a determinant of the ability of platelets to stimulate proliferation of endothelial cells (ECs) and smooth muscle cells (SMCs). Platelets were obtained from 24 patients (two groups of 12 patients each) with insulin-dependent diabetes mellitus (IDDM) and increased blood glucose concentrations (HbA1c > 10% Hb), duration of disease 2-45 years, on no other medication than insulin at the time of blood sampling or during the preceding 6 months, and with no signs of coronary artery disease, nephropathy, hypertension or retinopathy. The patients served as their own controls, platelets being obtained from them again 2-4 months later when their mean glucose values were lower (HbA1c < 6.5% Hb). EC proliferation was significantly reduced after exposure to platelets obtained from the patients when their metabolic control had improved, whereas no significant differences were seen in either SMC proliferation or prostacyclin production. There was no correlation between changes in insulin dosage and either cell proliferation or prostacyclin production, or between changes in lipid values and cell proliferative capacity. It is concluded that, EC proliferatio...Continue Reading


Feb 1, 1992·Diabetes Research and Clinical Practice·L TóthL Romics
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R RossL Harker
Jul 1, 1983·The Journal of Clinical Investigation·Y Oka, D N Orth
May 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·P FalkeL Stavenow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.