Metabolic control of cancer cell stemness: Lessons from iPS cells

Cell Cycle
Javier A Menendez

Abstract

The Nobel prized discovery of nuclear reprogramming is swiftly providing mechanistic evidence of a role for metabolism in the generation of cancer stem cells (CSC). Traditionally, the metabolic demands of tumors have been viewed as drivers of the genetic programming detected in cancer tissues. Beyond the energetic requirements of specific cancer cell states, it is increasingly recognized that metabolism per se controls epi-transcriptional networks to dictate cancer cell fate, i.e., metabolism can define CSC. Here I review the CSC-related metabolic features found in induced pluripotent stem (iPS) cells to provide an easily understandable framework in which the infrastructure and functioning of cellular metabolism might control the efficiency and kinetics of reprogramming in the re-routing of non-CSC to CSC-like cellular states. I suggest exploring how metabolism-dependent regulation of epigenetics can play a role in directing CSC states beyond conventional energetic demands of stage-specific cancer cell states, opening a new dimension of cancer in which the "physiological state" of CSC might be governed not only by cell-autonomous cues but also by local micro-environmental and systemic metabolo-epigenetic interactions. Forthcomi...Continue Reading

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Citations

Oct 30, 2016·Cell Cycle·Elisabet CuyàsJavier A Menendez
Mar 1, 2017·Journal of Cellular and Molecular Medicine·Hengqiang ZhaoTao Yin
Sep 19, 2017·Expert Opinion on Therapeutic Targets·Javier A Menendez, Ruth Lupu
Jun 12, 2018·Cell Cycle·Elisabet CuyàsJavier A Menendez
Jul 28, 2018·Journal of Evidence-based Integrative Medicine·Mifetika LukitasariNashi Widodo
Jan 10, 2017·Annual Review of Pathology·Sriram Venneti, Craig B Thompson
Aug 18, 2020·Radiation Oncology·Kexu XiangJohann Matschke
Feb 26, 2016·Oncoscience·Salvador Fernández-ArroyoJavier A Menendez
May 10, 2018·European Journal of Nutrition·Jina ChoiSang-Woon Choi
Jun 14, 2016·Aging·Alejandro Vazquez-MartinJavier A Menendez
Aug 30, 2017·Frontiers in Immunology·Jelena KrsticDiana Bugarski
Oct 3, 2019·Cancer Research·Catherine J LibbyAnita B Hjelmeland
Aug 7, 2021·Stem Cell Reviews and Reports·Prajna Paramita NaikSujit Kumar Bhutia

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