Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila.

Communications Biology
Sang Hyuk LeeEun Young Kim

Abstract

Metabolism influences locomotor behaviors, but the understanding of neural curcuit control for that is limited. Under standard light-dark cycles, Drosophila exhibits bimodal morning (M) and evening (E) locomotor activities that are controlled by clock neurons. Here, we showed that a high-nutrient diet progressively extended M activity but not E activity. Drosophila tachykinin (DTk) and Tachykinin-like receptor at 86C (TkR86C)-mediated signaling was required for the extension of M activity. DTk neurons were anatomically and functionally connected to the posterior dorsal neuron 1s (DN1ps) in the clock neuronal network. The activation of DTk neurons reduced intracellular Ca2+ levels in DN1ps suggesting an inhibitory connection. The contacts between DN1ps and DTk neurons increased gradually over time in flies fed a high-sucrose diet, consistent with the locomotor behavior. DN1ps have been implicated in integrating environmental sensory inputs (e.g., light and temperature) to control daily locomotor behavior. This study revealed that DN1ps also coordinated nutrient information through DTk signaling to shape daily locomotor behavior.

References

Aug 12, 1999·Chronobiology International·N Mrosovsky
Feb 13, 2001·Science·K A StokkanM Menaker
Mar 22, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·R HaraS Shibata
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·T OsterwalderH Keshishian
Aug 5, 2003·The Journal of Comparative Neurology·Asa M E WintherDick R Nässel
Jun 14, 2005·Nature Reviews. Genetics·Deborah Bell-PedersenMark J Zoran
Nov 18, 2005·Molecular and Cellular Neurosciences·Asa M E WintherAlberto Ferrús
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dirk RiegerCharlotte Helfrich-Förster
Nov 7, 2007·Cell Metabolism·Akira KohsakaJoseph Bass
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Barret D PfeifferGerald M Rubin
Oct 22, 2008·The Journal of Physiology·Jorge MendozaEtienne Challet
Feb 17, 2009·Neuron·Michael D Gordon, Kristin Scott
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rickard IgnellAsa M E Winther
Feb 13, 2010·Annual Review of Physiology·Ravi Allada, Brian Y Chung
May 8, 2010·Progress in Neurobiology·Dick R Nässel, Asa M E Winther
Jun 15, 2010·The Journal of Experimental Biology·Lily KahsaiAsa M E Winther
Aug 11, 2010·Genetics·Barret D PfeifferGerald M Rubin
Aug 14, 2010·PloS One·James H CattersonPaul S Hartley
Apr 30, 2011·Physiology & Behavior·Ralph E Mistlberger
Aug 10, 2011·The Journal of Comparative Neurology·Christiane HermannCharlotte Helfrich-Förster
Feb 14, 2012·Genes & Development·Eun Young KimJin Won Cho
Feb 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anne Christina HergardenDavid J Anderson
Mar 1, 2012·Frontiers in Neurology·Hiroshi IshimotoToshihiro Kitamoto
Apr 10, 2012·Annual Review of Neuroscience·Jennifer A MohawkJoseph S Takahashi
Oct 9, 2012·Neuron·Paul H Taghert, Michael N Nitabach
Oct 16, 2012·Cell Reports·Arnim JenettChristopher T Zugates

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Software Mentioned

GeneSwitch
Rotor Gene Q - Pure Detection
Zen
Drosophila Activity Monitoring System
GRASP
GraphPad Prism5
nSyb
Trikinetics
ZEN Digital
ImageJ

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