PMID: 41878Aug 1, 1979

Metabolic control of neuronal pacemaker activity and the rhythmic organization of central nervous functions

The Journal of Experimental Biology
R A Chaplain


The endogenous rhythmic activity of isolated pacemaker neurones of Aplysia californica appears to be controlled by the operation of a substrate cycle. The recycling of fructose-6-phosphate is mediated by two membrane-bound enzymes: phosphofructokinase (PFK) and fructose-1,6-diphosphatase (FDPase). Allosteric effectors which promote the PFK-FDPase system either increase the regular beating activity or induce bursting discharges, while inhibitory effectors reduce pacemaker activity. Associated with the PFK-FDPase cycle are slow oscillations in membrane potential, the postulate being that changes in amplitude and time period of the waves are brought about by the cyclic fluctuations of H+ ions and ATP in the immediate vicinity of the membrane. Other enzyme reactions which affect the concentrations of gluconeogenic substrates or PFK effectors can modulate the oscillatory driving input, a good example being the neurogenic amino acid glutamate. Modifiers of FDPase and PFK are equally effective in changing pacemaker activity within the intact neuronal network and, hence, the rhythmic body function connected to this network. This has been demonstrated with pacemaker neurones governing cardiovascular activity in Apylsia, blood pressure o...Continue Reading

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