Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis

Current Osteoporosis Reports
Russell T TurnerUrszula T Iwaniec

Abstract

Mesenchymal stem cells (MSCs) located in the bone marrow have the capacity to differentiate into multiple cell lineages, including osteoblast and adipocyte. Adipocyte density within marrow is inversely associated with bone mass during aging and in some pathological conditions, contributing to the prevailing view that marrow adipocytes play a largely negative role in bone metabolism. However, a negative association between marrow adipocytes and bone balance is not universal. Although MAT levels appear tightly regulated, establishing the precise physiological significance of MAT has proven elusive. Here, we review recent literature aimed at delineating the function of MAT. An important physiological function of MAT may be to provide an expandable/contractible fat depot, which is critical for minimization of energy requirements for sustaining optimal hematopoiesis. Because the energy requirements for storing fat are negligible compared to those required to maintain hematopoiesis, even small reductions in hematopoietic tissue volume to match a reduced requirement for hematopoiesis could represent an important reduction in energy cost. Such a physiological function would require tight coupling between hematopoietic stem cells and MS...Continue Reading

References

Oct 3, 1986·Biochimica Et Biophysica Acta·K HatanakaA Yamamoto
Sep 1, 1983·American Journal of Hematology·M Tavassoli, A Friedenstein
Jan 1, 1982·Metabolic Bone Disease & Related Research·T J Wronski, E R Morey
May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G F MuschlerK A Easley
Jun 5, 2002·AIDS·Jeannie S HuangSteven Grinspoon
Aug 27, 2002·Journal of Clinical Pathology·S VermaR J Byers
Apr 7, 2004·The Journal of Clinical Investigation·Liming Pei, Peter Tontonoz
Apr 7, 2004·The Journal of Clinical Investigation·Toru AkuneHiroshi Kawaguchi
May 11, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark W HamrickClifton A Baile
Feb 24, 2006·Nature Reviews. Immunology·Anne Wilson, Andreas Trumpp
Apr 22, 2008·Archives of Biochemistry and Biophysics·H Kalervo Väänänen, Tiina Laitala-Leinonen
Feb 25, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G F MaddalozzoU T Iwaniec
Oct 14, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Philip J MenaghUrszula T Iwaniec
Jul 31, 1936·The Journal of Experimental Medicine·C Huggins, B H Blocksom
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russell T TurnerJean D Sibonga
Aug 6, 2010·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Nicole M AgostinoJoseph J Drabick
Dec 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M Overton
Feb 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sun Wook ChoChan Soo Shin
Apr 27, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shoshana M BartellClifton A Baile
Jun 3, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Russell T TurnerUrszula T Iwaniec
Feb 18, 2012·Journal of Magnetic Resonance Imaging : JMRI·James F GriffithPing Chung Leung
Feb 22, 2012·The Journal of Experimental Medicine·Anna MansourClaudine Blin-Wakkach
Nov 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donte C SaucilloNancie J Maciver
Jan 17, 2014·Nature·Sean J Morrison, David T Scadden
Mar 19, 2014·IUBMB Life·Shanmugam Muruganandan, Christopher J Sinal
May 27, 2014·Current Opinion in Hematology·Shanti Rojas-SutterlinTrang Hoang
Jun 24, 2014·Archives of Biochemistry and Biophysics·Beata Lecka-Czernik, Lance A Stechschulte
Oct 16, 2014·Journal of Community Hospital Internal Medicine Perspectives·Eric OsgoodNishith Mewada
Feb 25, 2015·Bone·Pascal R Buenzli, Natalie A Sims
Mar 30, 2016·Current Opinion in Pharmacology·Karla J SuchackiClifford J Rosen

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Citations

Oct 15, 2018·Journal of Cellular Physiology·Filipe R CarvalhoPaulo J Gavaia
Oct 9, 2019·Journal of Biophotonics·Yuhao LiuShiwen Zhang
Jan 24, 2020·Current Osteoporosis Reports·Cristine Donham, Jennifer O Manilay
Jun 30, 2019·Scientific Reports·Jessica A KeuneRussell T Turner
May 22, 2019·Journal of Clinical Medicine·Vincent Cuminetti, Lorena Arranz
Sep 27, 2019·Alcoholism, Clinical and Experimental Research·Arianna M Kahler-QuesadaUrszula T Iwaniec
Oct 18, 2020·Current Osteoporosis Reports·Sarah E Little-LetsingerMaya Styner
Nov 26, 2020·Journal of Magnetic Resonance Imaging : JMRI·Umi Nabilah IsmailKwan Hoong Ng
Jul 15, 2021·Academic Radiology·Carolina Freitas LinsMarcello H Nogueira-Barbosa
Aug 15, 2021·Experimental Gerontology·Stephen A MartinViviana I Perez
Oct 9, 2021·Bone·Tareq Anani, Alesha B Castillo

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